ENGLISH

Optimization in Drug Discovery: In Vitro Methods

By Gary W. Caldwell , Becki Hasting , John A. Masucci (auth.) , Zhengyin Yan (eds.)

Book information

Publisher
Humana Press
Year
2014
ISBN
978-1-62703-741-9, 978-1-62703-742-6
DOI
10.1007/978-1-62703-742-6
Language
english
Format
PDF
Filesize
12 MB (12147801 bytes)
Series
Methods in Pharmacology and Toxicology
Edition
2
Pages
597\596
Time added
2013-12-12 02:00:00
Pharmacology/Toxicology

Description

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

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