Handbook of Copper Pharmacology and Toxicology

Description

Although copper is an essential trace element necessary for the survival of organisms ranging from bacteria to mammals, it is also highly toxic and must be absorbed by the body in precisely orchestrated biological processes. In Handbook of Copper Pharmacology and Toxicology, Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general, and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases-Menkes and Wilson's diseases and occipital horn syndrome-as well as the role of copper in Parkinson's disease, prion disease, familial amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The elucidation of the precise mechanisms of copper trafficking, metabolism, and homeostasis will be of considerable importance in understanding the pathophysiology and treatment of such diseases. Comprehensive and timely, the Handbook of Copper Pharmacology and Toxicology authoritatively provides researchers with all the up-to-date information needed to work productively in copper biology today. Front Matter....Pages i-xvi Front Matter....Pages 1-1 Biochemistry and Molecular Biology of Copper in Mammals....Pages 3-32 Front Matter....Pages 33-33 Biochemistry of the Wilson’s Disease Protein....Pages 35-51 Biologically Relevant Properties of Copper-Containing Proteins Analyzed by Means of Semiquantitative and Quantitative Theoretical Descriptors....Pages 53-80 Molecular Modeling and Dynamics of Copper Proteins....Pages 81-101 The Prion Protein and Copper....Pages 103-113 Prion Protein....Pages 115-129 Cytochrome- c Oxidase....Pages 131-152 The Fet3 Protein....Pages 153-175 Interaction of Copper-Binding Proteins from Enterococcus hirae ....Pages 177-186 Front Matter....Pages 187-187 Copper Uptake in Eukaryotic Cells....Pages 189-199 The Role of PINA in Copper Transport, Circadian Rhythms, and Wilson’s Disease....Pages 201-207 The Identification of Motifs Involved in the Intracellular Trafficking of the Menkes Disease Protein....Pages 209-226 Intracellular Copper Transport and ATP7B, the Wilson’s Disease Protein....Pages 227-234 A Multicopper Oxidase-Based Iron-Transport System in Yeast....Pages 235-245 Front Matter....Pages 247-247 Molecular Basis of Diseases of Copper Homeostasis....Pages 249-276 Disturbances of Copper Homeostasis and Brain Function....Pages 277-296 Role of Copper and Other Transition Metal Ions in the Pathogenesis of Parkinson’s Disease, Prion Diseases, Familial Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease....Pages 297-317 Molecular Genetics and Clinical Aspects of Menkes Disease and Occipital Horn Syndrome....Pages 319-332 The Meaning of Alternative Transcripts of the Menkes Disease Gene....Pages 333-341 Expression Profiling in Menkes Disease....Pages 343-356 Front Matter....Pages 247-247 Regulation by Copper of the Expression of Human Bis, a New Gene Involved in the Cellular Stress Response to Metals....Pages 357-367 Non-Indian Childhood Cirrhosis....Pages 369-382 Front Matter....Pages 383-383 Biological Effects of Chronic Copper Exposure....Pages 385-396 Copper Toxicity to Tight Junctions in the Human Intestinal Caco-2 Cell Line....Pages 397-416 Cellular Responses to Copper in Aquatic Organisms....Pages 417-431 Selective Removal of Copper Accumulating in the Form Bound to Metallothionein by Tetrathiomolybdate....Pages 433-442 Control of Copper in Wilson’s Disease and Diseases of Neovascularization, such as Cancer....Pages 443-460 Copper-Rich Metallothionein Polymers During the Development of Fulminant Hepatitis in LEC Rats....Pages 461-471 Front Matter....Pages 473-473 Sensory Protein Modification....Pages 475-480 Comparative Analysis of Copper and Iron Metabolism in Photosynthetic Eukaryotes vs Yeast and Mammals....Pages 481-502 Copper and the Morphological Development of Streptomyces ....Pages 503-525 Molecular Hardware of Copper Homeostasis in Enterococcus hirae ....Pages 527-542 Copper Homeostasis in Plants....Pages 543-557 The Role of Copper Ions in Regulating Methane Monooxygenases in Methanotrophs....Pages 559-569 Regulatory Responses to Copper Ions in Fungi....Pages 571-587 Back Matter....Pages 589-608