Tumor Models in Cancer Research

Description

Front Matter....Pages i-xv Front Matter....Pages 1-1 Perspective on the History of Tumor Models....Pages 3-19 Front Matter....Pages 21-21 Murine L1210 and P388 Leukemias....Pages 23-40 Transplantable Syngeneic Rodent Tumors....Pages 41-71 B16 Murine Melanoma....Pages 73-89 Front Matter....Pages 91-91 Xenotransplantation of Human Cell Cultures in Nude Mice....Pages 93-97 GFP-Expressing Metastatic-Cancer Mouse Models....Pages 99-112 Human Tumor Xenografts and Explants....Pages 113-137 Front Matter....Pages 139-139 Hamster Oral Cancer Model....Pages 141-171 Mammary Cancer in Rats....Pages 173-181 Carcinogen-Induced Colon-Cancer Models for Chemoprevention and Nutritional Studies....Pages 183-191 Front Matter....Pages 193-193 Cancer Models....Pages 195-222 Cyclin D1 Transgenic Mouse Models....Pages 223-230 Mice Expressing the Human Carcinoembryonic Antigen....Pages 231-246 The p53 -Deficient Mouse as a Cancer Model....Pages 247-261 The Utility of Transgenic Mouse Models for Cancer Prevention Research....Pages 263-274 Front Matter....Pages 275-275 Metastasis Models....Pages 277-291 Models for Evaluation of Targeted Therapies of Metastatic Disease....Pages 293-319 Front Matter....Pages 321-321 Animal Models of Oral Mucositis Induced by Antineoplastic Drugs and Radiation....Pages 323-335 The Intestine as a Model for Studying Stem-Cell Behavior....Pages 337-357 SENCAR Mouse-Skin Tumorigenesis Model....Pages 359-380 Front Matter....Pages 321-321 Murine Models of Bone-Marrow Transplant Conditioning....Pages 381-405 Anesthetic Considerations for the Study of Murine Tumor Models....Pages 407-431 Front Matter....Pages 433-433 Tissue-Isolated Tumors in Mice....Pages 435-451 Human Breast-Cancer Xenografts as Models of the Human Disease....Pages 453-470 Animal Models of Melanoma....Pages 471-492 Experimental Animal Models for Renal Cell Carcinoma....Pages 493-505 Animal Models of Mesothelioma....Pages 507-520 SCID Mouse Models of Human Leukemia and Lymphoma as Tools for New Agent Development....Pages 521-540 Models for Studying the Action of Topoisomerase-I Targeted Drugs....Pages 541-563 Spontaneous Pet Animal Cancers....Pages 565-589 Front Matter....Pages 591-591 In Vivo Tumor Response End Points....Pages 593-616 Tumor-Cell Survival....Pages 617-631 Apoptosis in Vivo....Pages 633-645 Transparent Window Models and Intravital Microscopy....Pages 647-671 Back Matter....Pages 673-690