Pharmacological Mechanisms in Alzheimer's Therapeutics

Description

Alzheimer’s is the most common dementia in the elderly. The need for effective therapy of dementia is greater than ever, but there is not, as yet, a drug therapy which can stop or reverse the clinical consequences. There is, however, a great deal of anticipation on the imminent development of effective, disease-modifying therapies. The remarkable progress made by the scientific community in unraveling molecular and cellular aspects of the Alzheimer’s pathology has allowed the identification of a number of promising targets for drug development. Investigation of these targets and the evolution of ongoing strategies to develop efficacious therapies for this devastating neurodegenerative condition is the central theme of Pharmacological Mechanisms in Alzheimer’s Therapeutics. The current and future therapies based on this new knowledge of the Alzheimer’s pathology are dealt with by contributors who have been most influential in bringing this new knowledge and in the development of experimental and presently applied therapies. The book should be of interest to medical professionals and basic scientists alike since it provides ideas about current trends in Alzheimer’s therapeutics to the general public. Front Matter....Pages i-xx Overview of the Alzheimer's Disease Pathology and Potential Therapeutic Targets....Pages 1-27 Trial Designs and Outcomes to Monitor Novel Therapeutics in Alzheimer's Disease....Pages 28-35 The Pharmacological Treatment of Alzheimer's Disease with Cholinesterase Inhibitors and Memantine....Pages 36-49 M1 Muscarinic Agonists: A Comprehensive Therapy Against Major Hallmarks of Alzheimer's Disease....Pages 50-63 Cholinergic Neurodegeneration in Alzheimer's Disease: Basis for Nerve Growth Factor Therapy....Pages 64-104 The Rationale for Glutamatergic Therapy in Alzheimer's Disease....Pages 105-112 Secretases as Pharmacological Targets in Alzheimer's Disease....Pages 113-124 γ-Secretase as a Target for Alzheimer's Disease....Pages 125-140 The Rationale for an Immunological Approach to Alzheimer's Therapeutics....Pages 141-148 Neuroinflammation, Alzheimer Disease, and Other Aging Disorders....Pages 149-166 Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Derived Aβ42-Lowering Molecules for Treatment and Prevention of Alzheimer's Disease (AD)....Pages 167-193 The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics....Pages 194-211 Apolipoprotein E: A Potent Gene-Based Therapeutic Target for the Treatment of Sporadic Alzheimer's Disease....Pages 212-222 Tau Pathology as a Target in Alzheimer's Therapeutics....Pages 223-237 Design of Inhibitors of Amyloid-β Misfolding and Aggregation for Alzheimer's Therapy....Pages 238-254 Potential Applications of Glycosaminoglycan-Related Compounds in Alzheimer's Disease....Pages 255-273 Multifunctional Neuroprotective Drugs for the Treatment of Alzheimer's Disease....Pages 274-295 Interpreting Clinical Studies of Putative Therapeutics for Alzheimer's Disease: The Case of Statins and NSAIDs....Pages 296-308 Back Matter....Pages 309-319