TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

Description

This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book’s final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike. Front Matter ....Pages i-x Introduction: How We Encountered TCTP and Our Purpose in Studying It (Adam Telerman, Robert Amson)....Pages 1-8 Structural Insights into TCTP and Its Interactions with Ligands and Proteins (Nadine Assrir, Florian Malard, Ewen Lescop)....Pages 9-46 Structure-Function Relationship of TCTP (Beatriz Xoconostle-Cázares, Roberto Ruiz-Medrano)....Pages 47-68 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation (Ulrich-Axel Bommer)....Pages 69-126 Current Understanding of the TCTP Interactome (Siting Li, Feng Ge)....Pages 127-136 Role and Fate of TCTP in Protein Degradative Pathways (Michel Vidal)....Pages 137-148 Roles of the Translationally Controlled Tumor Protein (TCTP) in Plant Development (Léo Betsch, Julie Savarin, Mohammed Bendahmane, Judit Szecsi)....Pages 149-172 Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies (Kwang-Wook Choi, Sung-Tae Hong, Thao Phuong Le)....Pages 173-191 Translationally Controlled Tumor Protein (TCTP/HRF) in Animal Venoms (Andrea Senff-Ribeiro)....Pages 193-200 Tctp in Neuronal Circuitry Assembly (Cláudio Gouveia Roque, Christine E. Holt)....Pages 201-215 Elusive Role of TCTP Protein and mRNA in Cell Cycle and Cytoskeleton Regulation (Jacek Z. Kubiak, Malgorzata Kloc)....Pages 217-225 The Translationally Controlled Tumor Protein and the Cellular Response to Ionizing Radiation-Induced DNA Damage (Jie Zhang, Grace Shim, Sonia M. de Toledo, Edouard I. Azzam)....Pages 227-253 TCTP Has a Crucial Role in the Different Stages of Prostate Cancer Malignant Progression (Virginie Baylot, Sara Karaki, Palma Rocchi)....Pages 255-261 Role of TCTP for Cellular Differentiation and Cancer Therapy (Ean-Jeong Seo, Nicolas Fischer, Thomas Efferth)....Pages 263-281 Targeting TCTP with Sertraline and Thioridazine in Cancer Treatment (Robert Amson, Christian Auclair, Fabrice André, Judith Karp, Adam Telerman)....Pages 283-290 History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) Including a Potential Therapeutic Target in Asthma and Allergy (Susan M. MacDonald)....Pages 291-308 Back Matter ....Pages 309-309