Melanoma Development: Molecular Biology, Genetics and Clinical Application

Description

The book provides comprehensive insights into molecular changes in malignant melanoma. The general mechanisms of melanoma growth and development are described, as well as new research findings. Our current knowledge on the molecules involved in cell transformation and tumor progression will soon lead to sophisticated, targeted therapies. Recent studies with targeted b-RAF inhibitors have given us grounds to hope that these therapies will be successful. Melanoma Development- Molecular Biology, Genetics and Clinical Application aims to contribute to this knowledge. Summarizing the newest data and presenting upcoming research areas in the field, the book will be of great interest to basic researchers and physicians working in the important fields of melanoma, cancer research, therapy and dermatology. Front Matter....Pages i-xi Introduction....Pages 1-5 Epidermal Melanocytes: Regulation of Their Survival, Proliferation, and Function in Human Skin....Pages 7-33 Melanoma Epidemiology....Pages 35-55 Melanoma Genetics and Genomics....Pages 57-77 Transcriptional Regulation in Melanoma....Pages 79-103 miRNAs in Malignant Melanoma....Pages 105-136 Altered Signal Transduction Pathways in Melanoma....Pages 137-163 Proteases in Melanoma....Pages 165-179 Cell–Cell and Cell–Matrix Contacts in Melanoma and the Tumor Microenvironment....Pages 181-215 Regulation of Apoptosis in Melanoma Cells: Targets for Therapeutic Strategies....Pages 217-233 Senescence....Pages 235-254 Melanoma Stem Cells....Pages 255-279 Lessons from Embryogenesis....Pages 281-296 Tumor Microenvironment for Melanoma Cells....Pages 297-307 Melanoma Model Systems....Pages 309-335 New Therapeutic Approaches in Signaling....Pages 337-357 Immunotherapy of Melanoma: A New Era....Pages 359-372 Back Matter....Pages 373-373