Chemokines and Cancer

Description

Chemokines and Cancer synthesizes a state-of-the-art understanding of the role that chemokines and their receptors play in the pathophysiology of malignancy. It examines the influence of chemokines on a broad array of malignant cells, including their effects on such intrinsic properties as growth and movement, as well as exploring their influence on the host's response to a growing tumor. The authors also demonstrate the physiological consequences of chemokine expression and suggest how chemokines can be used to regulate tumor growth in vivo, including their direct effects on tumor growth, on tumor destruction by host inflammatory cells, and on tumor angiogenesis. The only book available that relates chemokines to cancer, Chemokines and Cancer holds out the promise of novel therapeutic approaches to malignancy through the manipulation of chemokines and/or their receptors. Front Matter....Pages i-xii Front Matter....Pages 1-1 The Function of Chemokines in Health and Disease....Pages 3-19 Chemokine Receptors and Ligand Specificity....Pages 21-31 Front Matter....Pages 33-33 Tumors as a Paradigm for the In Vivo Role of Chemokines in Leukocyte Recruitment....Pages 35-49 Novel Monocyte Chemoattractants in Cancer....Pages 51-69 Front Matter....Pages 71-71 Natural Killer Cell-Chemokine Interactions....Pages 73-93 Tumor Infiltration by Monocytes and the Antitumor Effects of Monocyte Chemoattractant Protein-1....Pages 95-113 Interactions Between Chemokines and Other Cytokines in Host Response to Tumor....Pages 115-126 Front Matter....Pages 127-127 Chemokine Modulation of Tumor Cell Physiology....Pages 129-141 C-X-C Chemokines and Lung Cancer Angiogenesis....Pages 143-167 The Role of Melanoma Growth-Stimulatory Activity in Melanoma Tumorigenesis and Angiogenesis....Pages 169-189 Front Matter....Pages 191-191 Chemokines and Gynecologic Malignancies....Pages 193-205 The Possible Role of Chemokines in HPV-Linked Carcinogenesis....Pages 207-225 Chemokines and Central Nervous System Malignancies....Pages 227-241 Chemokines and Helicobacter pylori Infection....Pages 243-259 Front Matter....Pages 261-261 Chemokines and Hematopoiesis....Pages 263-291 Macrophage Inflammatory Protein-1α and Stem Cell Inhibition....Pages 293-310 Back Matter....Pages 311-321