Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs: Cell Signaling Pathways and microRNAs in Cancer Biology

Description

Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments. Front Matter ....Pages i-xii From Endometriosis to Cancer: Spotlight on Intracellular Signaling Cascades and MicroRNAs (Talha Abdul Halim, Rukset Attar, Cristina Donfrancesco, Ammad Ahmad Farooqi, Farrukh Zaman)....Pages 1-10 Tyrosine Kinases, microRNAs, Epigenetics: New Insights in the Mechanisms of Leukemogenesis (Maria Ciccone, George A. Calin)....Pages 11-25 The Emerging Role of Exosomes in Cancer Progression and Their Potential as Therapy Targets (Carolina F. Ruivo, Sónia A. Melo)....Pages 27-45 Tranquilizing and Awakening ATM to Promote Killing of Cancer Cells (Yi Chieh Lim, Shahzad Bhatti, Ammad Ahmad Farooqi)....Pages 47-58 The Role of GPER Signaling in Carcinogenesis: A Focus on Prostate Cancer (Marília I. Figueira, Henrique J. Cardoso, Sílvia Socorro)....Pages 59-117 Bone Cancer: Dysregulation of Signaling Cascades by microRNAs (Janaina de Andréa Dernowsek)....Pages 119-128 The Roles of miR-25 and Its Targeted Genes in Human Cancer (Carmen Caiazza, Palmiro Poltronieri, Massimo Mallardo)....Pages 129-139 Notch Signaling in Lung Cancer Initiation and Development (Kayla C. Lewis, Yi Liu)....Pages 141-149 TGF-β/Smad Signalling Pathway in Cancer (Mohadeseh Hasanpourghadi, Mohd. Rais Mustafa)....Pages 151-185 Natural Agents Mediated Regulation of microRNAs: Do We Need Skilled Archers to Hit the Bullseye (Eun Jung Sohn, Ammad Ahmad Farooqi, Hwan Tae Park)....Pages 187-197 Sebaceous Carcinoma of the Eyelid (Armando Luis Garcia, Ke Jin, Ravi Doddapaneni, Catherine Jeeyun Choi, Maria Paula Fernandez, Sander Dubovy et al.)....Pages 199-220 Current Knowledge of miRNAs as Biomarkers in Breast Cancer (Maria Luisa Gasparri, Zein Mersini Besharat, Aris Raad Besharat, Ilary Ruscito, Konstantinos Nirgianakis, Ammad Ahmad Farooqi et al.)....Pages 221-231 Signaling Landscape of AML: The Story So Far (Chiara Martinelli)....Pages 233-262 When the Molecules Start Playing Chess, or How MicroRNAs Acquire Dualistic Activity During Cancer Progression (Krassimira Todorova, Soren Hayrabedyan)....Pages 263-277 The Crosstalk Between miRNAs and Autophagy in Cancer Progression (Bayraktar Oznur, Gozuacik Devrim)....Pages 279-291 Role of CEACAM in Different Cancers (Ilhan Yaylim, Ghazala Butt, Sumbul Khalid, Ammad Ahmad Farooqi)....Pages 293-300 Back Matter ....Pages 301-308