ENGLISH

Molecular Toxicology Protocols

By David H. Phillips , Alan Hewer , Volker M. Arlt (auth.) , Phouthone Keohavong , Stephen G. Grant (eds.)

Book information

Publisher
Humana Press
Year
2005
ISBN
9781588290847, 1588290840, 1592598404
DOI
10.1385/1592598404
Open Library ID
OL17151392M
Language
english
Format
PDF
Filesize
11 MB (11039717 bytes)
Series
Methods in Molecular Biology 291
Edition
1
Pages
505\505
Time added
2010-08-30 15:18:36
Pharmacology/Toxicology

Description

A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.

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