Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Description

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike. Front Matter ....Pages i-viii Front Matter ....Pages 1-1 Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation (Yosuke Togashi, Hiroyoshi Nishikawa)....Pages 3-27 Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells (Keishi Fujio, Kazuhiko Yamamoto, Tomohisa Okamura)....Pages 29-45 Regulatory Dendritic Cells (Katsuaki Sato, Tomofumi Uto, Tomohiro Fukaya, Hideaki Takagi)....Pages 47-71 Front Matter ....Pages 73-73 Role of PD-1 in Immunity and Diseases (Kenji Chamoto, Muna Al-Habsi, Tasuku Honjo)....Pages 75-97 CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation (Shunsuke Chikuma)....Pages 99-126 Tim-3, Lag-3, and TIGIT (Nicole Joller, Vijay K. Kuchroo)....Pages 127-156 Front Matter ....Pages 157-157 SOCS1: Regulator of T Cells in Autoimmunity and Cancer (Subburaj Ilangumaran, Diwakar Bobbala, Sheela Ramanathan)....Pages 159-189 Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity (Claudia Penafuerte, Luis Alberto Perez-Quintero, Valerie Vinette, Teri Hatzihristidis, Michel L. Tremblay)....Pages 191-214 Immune Regulation by Ubiquitin Tagging as Checkpoint Code (Peng Zeng, Jieyu Ma, Runqing Yang, Yun-Cai Liu)....Pages 215-248 MicroRNA in Immune Regulation (Cheng-Jang Wu, Li-Fan Lu)....Pages 249-267