Physeo Immunology
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MEDICAL COURSE AND STEP 1 REVIEW FIRST EDITION Accompanies online videos taught by Rhett Thomson & Michael Christensen. physeo.com IMMUNOLOGY.....................................................................................................................4 Section I - Lymphoid Structures ................................................................................................................................................... 4 Section II - Acute Inflammation.................................................................................................................................................. 10 Section III - Neutrophils ............................................................................................................................................................. 14 Section IV - Kinin....................................................................................................................................................................... 17 Section V - Complement............................................................................................................................................................. 20 Section VI - Chronic Inflammation............................................................................................................................................. 23 Section VII - Major Histocompatibility Complexes................................................................................................................... 27 Section VIII - Macrophages........................................................................................................................................................ 33 Section VIII.1 - Cytokines from Macrophages and Dendritic Cells........................................................................................... 37 Section IX - NK Cells and Cytotoxic T Cells............................................................................................................................. 38 Section X - Positive and Negative Selection .............................................................................................................................. 40 Section XI - T-cell Activation and Subtypes............................................................................................................................... 42 Section XI.1 - Cytokines from Th1 and NK Cells...................................................................................................................... 44 Section XI.2 - Cytokines from Th2 Cells ................................................................................................................................... 45 Section XI.3 - Cytokines from Th17 Cells ................................................................................................................................. 46 Section XI.4 - Cytokines from Treg Cells .................................................................................................................................. 47 Section XII - Antibodies ............................................................................................................................................................. 48 Section XIII - B-cells.................................................................................................................................................................. 51 Section XIV - Vaccinations......................................................................................................................................................... 56 Section XV - Hypersensitivity Reactions ................................................................................................................................... 60 Section XVI - Blood Transfusion Reactions............................................................................................................................... 65 Section XVII - Transplant Rejection........................................................................................................................................... 69 IMMUNODEFICIENCIES..................................................................................................71 Section I - Bruton Agammaglobulinemia ................................................................................................................................... 71 Section II - Selective IgA Deficiency.......................................................................................................................................... 72 Section III - Common Variable Immunodeficiency (CVID)....................................................................................................... 73 Section IV - Thymic Aplasia....................................................................................................................................................... 74 Section V - IL-12 Receptor Deficiency....................................................................................................................................... 75 Section VI - Job Syndrome ......................................................................................................................................................... 77 Section VII - Chronic mucocutaneous candidiasis ..................................................................................................................... 78 Section VIII - Severe combined immunodeficiency (SCID) ...................................................................................................... 79 Section IX - Ataxia-telangiectasia .............................................................................................................................................. 80 Section X - Hyper-IgM syndrome .............................................................................................................................................. 81 Section XI - Wiskott-Aldrich Syndrome..................................................................................................................................... 82 Section XII - Leukocyte Adhesion Deficiency ........................................................................................................................... 83 Section XIII - Chediak-Higashi syndrome ................................................................................................................................. 84 Section XIV - Chronic Granulomatous Disease ......................................................................................................................... 85
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