ENGLISH

NF-kB in Health and Disease

By Alexander Hoffmann , Tom Huxford , Gourisankar Ghosh (auth.) , Michael Karin (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2011
ISBN
3642160166, 9783642160165
DOI
10.1007/978-3-642-16017-2
ISSN
0070-217X
Google Books ID
Bvlthv-7muwC
Language
english
Format
PDF
Filesize
2 MB (2544923 bytes)
Series
Current Topics in Microbiology and Immunology 349
Edition
1
Pages
268\278
Orientation
yes
Scanned
no
Time added
2011-08-31 04:54:40
Cancer Research

Description

This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.

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