ENGLISH

Chromosomal Instability in Cancer Cells

By Thomas Ried (eds.) , B. Michael Ghadimi

Book information

Publisher
Springer International Publishing
Year
2015
ISBN
978-3-319-20290-7, 978-3-319-20291-4
DOI
10.1007/978-3-319-20291-4
Language
english
Format
PDF
Filesize
6 MB (5840646 bytes)
Series
Recent Results in Cancer Research 200
Edition
1
Pages
VII, 224\228
Time added
2015-11-25 16:51:03
Oncology; Cancer Research; Human Genetics

Description

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

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