Cancer Genetics

Description

Cancer genetics has revolutionized the practice of medicine as inherited genetic information helps predicts which individuals are at risk of developing various forms of cancer. Furthermore, somatically acquired genetic changes help identify therapeutic targets for patients with several common tumor types such as breast and colon cancer. Cancer Genetics reviews seminal discoveries such as genetic susceptibility to gastric cancer, ethical issues related to cancer genetics, the role of common variants in the development of breast cancer, novel genetic findings related to neuroblastoma, and the role of constitutively decreased TGF-beta signaling, which is emerging as one of the most common causes of colorectal cancer. The book has been written for all clinicians and researchers interested in cancer genetics, including oncologists, genetic counselors and cancer researchers both in academia and in industry. "Genetic alterations are a fundamental component of all cancers. This text highlights critical issues relevant for both basic scientists and clinicians. Recognized thought leaders in the field discuss current knowledge and future challenges." - Steven T. Rosen, M.D., Series Editor Front Matter....Pages i-xii Ethicolegal Aspects of Cancer Genetics....Pages 1-14 The Influence of Common Polymorphisms on Breast Cancer....Pages 15-32 Hereditary Diffuse Gastric Cancer....Pages 33-63 Genetics and Genomics of Neuroblastoma....Pages 65-84 TGF-β Signaling Alterations and Colon Cancer....Pages 85-103 Back Matter....Pages 105-112