Next Generation Point-of-care Biomedical Sensors Technologies for Cancer Diagnosis

Description

This book presents recent research on cancer detection methods based on nanobiosensors, which offer ultrasensitive point-of-care diagnosis. Several methods for diagnosing cancer have been discovered and many more are currently being developed. Conventional clinical approaches to detecting cancers are based on a biopsy followed by histopathology, or on the use of biomarkers (protein levels or nucleic acid content). Biopsy is the most widely used technique; however, it is an invasive technique and is not always applicable. Furthermore, biomarker-based detection cannot be relied on when the biomarkers are present in an extremely low concentration in the body fluids and in malignant tissues. Thus, in recent years highly sensitive and robust new cancer diagnosis techniques have been developed for clinical application, and may offer an alternative strategy for cancer diagnosis. As such, this book gathers the latest point-of-care cancer diagnostic methods and protocols based on biomedical sensors, microfluidics, and integrated systems engineering. It also discusses recent developments and diagnostics tests that can be conducted outside the laboratory in remote areas. These technologies include electrochemical sensors, paper-based microfluidics, and other kit-based diagnostic methods that can be adapted to bring cancer detection and diagnostics to more remote settings around the globe. Overall, the book provides students, researchers, and clinicians alike a comprehensive overview of interdisciplinary approaches to cancer diagnosis. Front Matter ....Pages i-xii Cancer Biomarkers: Important Tools for Cancer Diagnosis and Prognosis (Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik, Ajaikumar B. Kunnumakkara)....Pages 1-29 Transcription Factors as Detection and Diagnostic Biomarkers in Cancer (W. L. Goh, E. Assah, X. T. Zheng, D. P. Lane, F. J. Ghadessy, Y. N. Tan)....Pages 31-58 Cancer Biomarker Immunosensing Monitoring Strategies via Graphene Surface-Engineered Materials (Shabi Abbas Zaidi)....Pages 59-81 Label-Free Biosensors for Early Diagnosis of Cancer Based on G-Quadruplex and Isothermal Amplification (Yahui Guo, Weirong Yao, Renjun Pei)....Pages 83-114 Point-of-Care and Implantable Biosensors in Cancer Research and Diagnosis (Christina G. Siontorou, Georgia-Paraskevi D. Nikoleli, Dimitrios P. Nikolelis, Stephanos Karapetis, Nikolaos Tzamtzis, Spyridoula Bratakou)....Pages 115-132 Electrochemical Redox Cycling Amplification Technology for Point-of-Care Cancer Diagnosis (Gorachand Dutta)....Pages 133-154 Hyperbolic Metamaterial-Based Ultrasensitive Plasmonic Biosensors for Early-Stage Cancer Detection (G. Strangi, K. V. Sreekanth, M. Elkabbash)....Pages 155-172 SERS-Based Biosensors as Potential Next-Generation Point-of-Care Cancer Diagnostic Platforms (Shounak Roy, Amit Jaiswal)....Pages 173-204 Nucleic Acid-Based Aptasensors for Cancer Diagnostics: An Insight into Immobilisation Strategies (Pawan Jolly, Marina R. Batistuti, Serife Ustuner, Marcelo Mulato, Sunil K. Arya, Pedro Estrela)....Pages 205-231 Nanobiosensing Technologies for Prostate Cancer Diagnostics/Prognostics: Tiny Smart Medicine (Renu Singh, Chandini C. Mohan)....Pages 233-252 Developments in the Electrochemical Bionanosensors for the Predictive Diagnosis of Prostate and Breast Cancer (Suman Singh, Akash Deep, Girish Mohanta, Vijay Kumar Meena)....Pages 253-278 Oligopeptides for Cancer and Other Biomedical Sensing Applications (Xiaokang Ding, Kun-Lin Yang)....Pages 279-304 Microfluidic Immunoassay Devices as Next-Generation Cancer and Medical Diagnostics Platform (Toshihiro Kasama, Yoshinobu Baba, Manabu Tokeshi)....Pages 305-322 Point-of-Care Device with Plasmonic Gold Nanoarray Sensing Chip for Biomarker Detections (Xiaodong Zhou, Ten It Wong, Ling Ling Sun, Jie Deng)....Pages 323-343 SERS Biosensing and Bioimaging: Design and Applications in Cancer Diagnostics (Kien Voon Kong)....Pages 345-364 Microfluidic Paper-Based Analytical Devices for Point-of-Care Diagnosis (Zhuan Zhuan Shi, Yao Lu, Ling Yu)....Pages 365-396