Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

Description

The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy. Front Matter ....Pages i-xiv Tumor Immuno-Environment in Cancer Progression and Therapy (Pawel Kalinski, James E. Talmadge)....Pages 1-18 Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment (Thomas F. Gajewski, Leticia Corrales, Jason Williams, Brendan Horton, Ayelet Sivan, Stefani Spranger)....Pages 19-31 Regulation of CTL Infiltration Within the Tumor Microenvironment (Sarah E. Church, Jérôme Galon)....Pages 33-49 The Role of Tumor Microenvironment in Cancer Immunotherapy (Timothy Frankel, Mirna Perusina Lanfranca, Weiping Zou)....Pages 51-64 Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment (Jonathan M. Pitt, Guido Kroemer, Laurence Zitvogel)....Pages 65-79 Exosomes in Cancer: Another Mechanism of Tumor-Induced Immune Suppression (Theresa L. Whiteside)....Pages 81-89 Chemo-Immunotherapy: Role of Indoleamine 2,3-Dioxygenase in Defining Immunogenic Versus Tolerogenic Cell Death in the Tumor Microenvironment (Theodore S. Johnson, Tracy Mcgaha, David H. Munn)....Pages 91-104 Targeting Myeloid-Derived Suppressor Cells in Cancer (Waseem Anani, Michael R. Shurin)....Pages 105-128 Tryptophan Catabolism and Cancer Immunotherapy Targeting IDO Mediated Immune Suppression (Adaobi Amobi, Feng Qian, Amit A. Lugade, Kunle Odunsi)....Pages 129-144 Lipid Inflammatory Mediators in Cancer Progression and Therapy (Saraswoti Khadge, John Graham Sharp, Timothy R. McGuire, Geoffrey M. Thiele, James E. Talmadge)....Pages 145-156 Oncolytic Virotherapy and the Tumor Microenvironment (Sara E. Berkey, Steve H. Thorne, David L. Bartlett)....Pages 157-172 The Impact of Housing Temperature-Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous System (Bonnie L. Hylander, Jason W.-L. Eng, Elizabeth A. Repasky)....Pages 173-189 Immunotherapeutic Targeting of Tumor-Associated Blood Vessels (Kellsye L. Fabian, Walter J. Storkus)....Pages 191-211 Adaptive Resistance to Cancer Immunotherapy (A. J. Robert McGray, Jonathan Bramson)....Pages 213-227 Imaging the Tumor Microenvironment (Marie-Caline Z. Abadjian, W. Barry Edwards, Carolyn J. Anderson)....Pages 229-257 Back Matter ....Pages 259-264