Combination Vaccines: Development, Clinical Research, and Approval

Description

A diverse team of leading experts comprehensively review the complex biology of a wide variety of vaccine combinations, as well as the technical, clinical, and regulatory aspects of their development. Topics covered range from the use of immunological correlates of efficacy, rather than efficacy per se, for the evaluation and licensure of vaccine combinations, to preserving a stable immunogenic mixture in appropriate containers according to accepted regulatory standards. Discussed in detail are the trivalent influenza vaccine, the pneumococcal polysaccharide vaccine, the MMR vaccine, the DTP vaccine and its combinations, and the quadrivalent rotavirus vaccine, all of which serve as models for the development of future combinations. Combination Vaccines: Development, Clinical Research, and Approval illuminates all the scientific, clinical, regulatory, and health care issues involved in the research, development, and human use of combination vaccines. Front Matter....Pages i-xvi Pediatric Combination Vaccines....Pages 1-33 Combination Vaccines in Adolescents and Adults....Pages 35-50 Pharmaceutical Aspects of Combination Vaccines....Pages 51-93 Pediatric Combination Vaccines....Pages 95-106 Immunological Correlates for Efficacy of Combination Vaccines....Pages 107-131 Influenza Vaccines....Pages 133-153 Vaccines Against Streptococcus pneumoniae ....Pages 155-169 Rotavirus Vaccines....Pages 171-195 Combined Measles, Mumps, and Rubella Vaccines....Pages 197-211 Combination Vaccines....Pages 213-231 Testing and Licensure of Combination Vaccines for the Prevention of Infectious Diseases....Pages 233-248 Issues for Health Practitioners in the Use of Combination Vaccines....Pages 249-267 Back Matter....Pages 269-279