Biochemistry and Metabolism

Description

This comprehensive treatise on the reticuloendothelial system is a project jointly shared by individual members of the Reticuloendothelial (RE) Society and bio­ medical scientists in general who are interested in the intricate system of cells and molecular moieties derived from these cells which constitute the RES. It may now be more fashionable in some quarters to consider these cells as part of what is called the mononuclear phagocytic system or the lymphoreticular system. Nevertheless, because of historical developments and current interest in the subject by investigators from many diverse areas, it seems advantageous to present in one comprehensive treatise current information and knowledge con­ of the RES, such as morphology, biochemistry, phylogeny cerning basic aspects and ontogeny, physiology, and pharmacology as well as clinical areas including immunopathology, cancer, infectious diseases, allergy, and hypersensitivity. It is anticipated that by presenting information concerning these apparently heterogeneous topics under the unifying umbrella of the RES attention will be focused on the similarities as well as interactions among the cell types constitut­ ing the RES from the viewpoint of various disciplines. The treatise editors and their editorial board, consisting predominantly of the editors of individual vol­ umes, are extremely grateful for the enthusiastic cooperation and enormous task undertaken by members of the biomedical community in general and especially by members of the American as well as European and Japanese Reticuloendothe­ lial Societies. Front Matter....Pages i-xxiv Biochemical and Biological Aspects of Leukocyte Chemotactic Factors....Pages 1-19 Attachment and Recognition Factors in the Interaction between Microbes and Mononuclear Phagocytes....Pages 21-43 Biochemistry and Physiology of Tuftsin Thr-Lys-Pro-Arg....Pages 45-71 Carbohydrate Metabolism....Pages 73-89 Lipid Metabolism by Phagocytic Cells....Pages 91-119 Glutathione Metabolism in Leukocytes....Pages 121-151 Metabolic Changes Accompanying Phagocytosis....Pages 153-188 The Oxidative Metabolism of Monocytes....Pages 189-229 Myeloperoxidase....Pages 231-254 Characteristics of Myeloperoxidase from Neutrophils and Other Peroxidases from Different Cell Types....Pages 255-278 Myeloperoxidase-Mediated Cytotoxic Systems....Pages 279-308 Free-Radical Production by Reticuloendothelial Cells....Pages 309-338 The Role of Oxygen Radicals in Microbial Killing by Phagocytes....Pages 339-354 Oxygen-Independent Antimicrobial Systems in Polymorphonuclear Leukocytes....Pages 355-368 Antimicrobial Functions of Phagocytes and Microbial Countermeasures....Pages 369-395 Biochemical Defects of Polymorphonuclear and Mononuclear Phagocytes Associated with Disease....Pages 397-421 Back Matter....Pages 423-432