ENGLISH

Lupus: Molecular and Cellular Pathogenesis

By Evelyn V. Hess (auth.) , Dr. Gary M. Kammer MD , Dr. George C. Tsokos MD (eds.)

Book information

Publisher
Humana Press
Year
1999
ISBN
978-1-4757-5686-9, 978-1-59259-703-1, 0-89603-536-0
DOI
10.1007/978-1-59259-703-1
Language
english
Format
PDF
Filesize
19 MB (19432577 bytes)
Series
Contemporary Immunology
Edition
1
Pages
709\727
Time added
2013-12-12 02:00:00
Immunology

Description

Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

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