DNA Modifications in the Brain. Neuroepigenetic Regulation of Gene Expression

Description

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Content: Front Matter,Copyright,List of Contributors,PrefaceEntitled to full textChapter 1 - History and Modern View on DNA Modifications in the Brain, Pages 1-25, B.F. Vanyushin, V.V. Ashapkin Chapter 2 - Approaches to Detecting DNA Base Modification in the Brain, Pages 27-41, X. Li, W. Wei Chapter 3 - Active DNA Demethylation in Neurodevelopment, Pages 43-59, Y. Kang, Z. Wang, P. Jin Chapter 4 - TET and 5hmC in Neurodevelopment and the Adult Brain, Pages 61-79, M. Fasolino, S.A. Welsh, Z. Zhou Chapter 5 - Beyond mCG: DNA Methylation in Noncanonical Sequence Context, Pages 81-94, E.A. Mukamel, R. Lister Chapter 6 - DNA Modifications and Memory, Pages 95-111, J.J. Day Chapter 7 - Measuring CpG Methylation by SMRT Sequencing, Pages 113-125, Y. Suzuki, J. Korlach, S. Morishita Chapter 8 - Epigenetic Modifications of DNA and Drug Addiction, Pages 127-147, J. Feng, E.J. Nestler Chapter 9 - What Does the Future Hold for the Study of Nucleic Acid Modifications in the Brain?, Pages 149-159, P.R. Marshall, T.W. Bredy Index, Pages 161-167