Biometals in Neurodegenerative Diseases. Mechanisms and Therapeutics

Description

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Content: Front matter,Copyright,Contributors,PrefaceEntitled to full textChapter 1 - Biometals and Alzheimer’s Disease, Pages 1-17, Alexandra I. Mot, Peter J. Crouch Chapter 2 - Copper in Alzheimer’s Disease, Pages 19-34, Rosanna Squitti, Mariacarla Ventriglia, Mariacristina Siotto, Carlo Salustri Chapter 3 - The Role of Selenium in Neurodegenerative Diseases, Pages 35-49, Bárbara R. Cardoso, Dominic J. Hare, Ashley I. Bush Chapter 4 - Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?, Pages 51-66, Anne M. Nixon, James R. Connor Chapter 5 - Chemical Elements and Oxidative Status in Neuroinflammation, Pages 67-81, Michela Ferraldeschi, Silvia Romano, Maria C. Buscarinu, Arianna Fornasiero, Rosella Mechelli, Benedetta Cerasoli, Anna Pino, Sonia Brescianini, Carlo Mattei, Maria A. Stazi, Alessandro Alimonti, Marco Salvetti, Giovanni Ristori Chapter 6 - Metals and Neuroinflammation, Pages 83-93, Stephen C. Bondy Chapter 7 - Metals and Prions: Twenty Years of Mining the Awe, Pages 95-115, David R. Brown Chapter 8 - Manganese and Neurodegeneration, Pages 117-151, Dinamene Marques dos Santos, Michael Aschner, Ana P. Marreilha dos Santos Chapter 9 - Zinc in Autism, Pages 153-173, Stefanie Grabrucker, Andreas M. Grabrucker Chapter 10 - Metals and Motor Neuron Disease, Pages 175-193, Per M. Roos Chapter 11 - Metals and Lysosomal Storage Disorders, Pages 195-215, Henna Konttinen, Katarína Lejavová, Tarja Malm, Katja M. Kanninen Chapter 12 - Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration, Pages 217-229, Lucio G. Costa Chapter 13 - Metal Biology Associated with Huntington’s Disease, Pages 231-263, Terry Jo V. Bichell, Timothy C. Halbesma, K. Grace Tipps, Aaron B. Bowman Chapter 14 - Metal-Binding to Amyloid-β Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production, Pages 265-281, Melisa del Barrio, Valentina Borghesani, Christelle Hureau, Peter Faller Chapter 15 - Metals and Mitochondria in Neurodegeneration, Pages 283-311, Germán Plascencia-Villa, Miguel José-Yacamán, George Perry Chapter 16 - Metal Transporters in Neurodegeneration, Pages 313-347, Hong Jiang Chapter 17 - Metal Imaging in the Brain, Pages 349-362, David C. Dorman Chapter 18 - Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases, Pages 363-376, Alejandra Ramírez Muñoz, Mark A. Greenough, Ashley I. Bush, Carlos M. Opazo Chapter 19 - Metals and Autophagy in Neurotoxicity, Pages 377-398, Peng Su, Michael Aschner, Jingyuan Chen, Wenjing Luo Chapter 20 - An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases, Pages 399-414, Frank W. Lewis, David Tétard Chapter 21 - Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases, Pages 415-438, Katja M. Kanninen, Anthony R. White Index, Pages 439-451