Disease-Modifying Targets in Neurodegenerative Disorders. Paving the Way for Disease-Modifying Therapies

Description

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Content: Front matter,Copyright,List of ContributorsEntitled to full textChapter 1 - The multitude of therapeutic targets in neurodegenerative proteinopathies, Pages 1-20, Ronald Melki Chapter 2 - Synuclein misfolding as a therapeutic target, Pages 21-47, Wouter Peelaerts, Tiago F. Outeiro Chapter 3 - Neuroinflammation as a therapeutic target in neurodegenerative diseases, Pages 49-80, Richard Gordon, Trent M. Woodruff Chapter 4A - Stem cells in neurodegeneration: mind the gap, Pages 81-100, Christel Claes, Joke Terryn, Catherine M. Verfaillie Chapter 4B - The potential of stem cells in tackling neurodegenerative diseases, Pages 101-114, Sarah Libbrecht Chapter 5 - Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy, Pages 115-156, Bruno Vasconcelos, Matthew Bird, Ilie-Cosmin Stancu, Dick Terwel, Ilse Dewachter Chapter 6 - Parkinson’s disease, Pages 157-174, Mark R. Cookson Chapter 7 - Lewy body dementia, Pages 175-198, Marion Delenclos, Simon Moussaud, Pamela J. McLean Chapter 8 - Frontotemporal dementia, Pages 199-249, Eline Wauters, Kristel Sleegers, Marc Cruts, Christine Van Broeckhoven Chapter 9 - From huntingtin gene to Huntington’s disease-altering strategies, Pages 251-276, Nicole Déglon Chapter 10 - Amyotrophic lateral sclerosis: mechanisms and therapeutic strategies, Pages 277-296, Ludo Van Den Bosch Index, Pages 297-305