Investigations of Early Nutrition Effects on Long-Term Health: Methods and Applications

Description

This volume contains several reviews in the field as well as the step-by-step use of targeted and global approaches within the areas of genomics, epigenetics, proteomics, transcriptomics and metabolomics which aim to address this dilemma and to help pinpoint new treatment strategies. Chapters detail the generation of several models and methods for assessing health and provide researchers potential approaches for reversing or minimizing effects of disease. In addition, important information on disease mechanisms is provided, as each method is described in the context of a specific disease or therapeutic area. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Investigations of Early Nutrition Effects on Long-Term Health: Methods and Applications aim is to provide insights into the latest ideas and technologies .enabling progress in this field. Front Matter ....Pages i-xiv Front Matter ....Pages 1-1 Nutritional Programming Effects on Development of Metabolic Disorders in Later Life (Thomas Prates Ong, Paul C. Guest)....Pages 3-17 Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease (Leslie Myatt, Kent L. Thornburg)....Pages 19-46 Developmental Origins of Stress and Psychiatric Disorders (Francesca L. Guest, Paul C. Guest)....Pages 47-58 Proteomic Studies of Psychiatric Disorders (Paul C. Guest)....Pages 59-89 Developmental Origins of Breast Cancer: A Paternal Perspective (Camile Castilho Fontelles, Raquel Santana da Cruz, Leena Hilakivi-Clarke, Sonia de Assis, Thomas Prates Ong)....Pages 91-103 Point-of-Care Testing and Personalized Medicine for Metabolic Disorders (Francesca L. Guest, Paul C. Guest)....Pages 105-114 Pregnancy and Lactation: A Window of Opportunity to Improve Individual Health (Guadalupe L. Rodríguez-González, Diana C. Castro-Rodríguez, Elena Zambrano)....Pages 115-144 Utility of Small Animal Models of Developmental Programming (Clare M. Reynolds, Mark H. Vickers)....Pages 145-163 Front Matter ....Pages 165-165 Generation of Maternal Obesity Models in Studies of Developmental Programming in Rodents (Paul D. Taylor, Phillippa A. Matthews, Imran Y. Khan, Douglas Rees, Nozomi Itani, Lucilla Poston)....Pages 167-199 Generation of the Maternal Low-Protein Rat Model for Studies of Metabolic Disorders (Dan Ma, Susan E. Ozanne, Paul C. Guest)....Pages 201-206 Investigation of Paternal Programming of Breast Cancer Risk in Female Offspring in Rodent Models (Camile Castilho Fontelles, Raquel Santana da Cruz, Leena Hilakivi-Clarke, Sonia de Assis, Thomas Prates Ong)....Pages 207-220 Studies of Isolated Peripheral Blood Cells as a Model of Immune Dysfunction (Hassan Rahmoune, Paul C. Guest)....Pages 221-229 Studies of a Neuronal Cell Line as a Model of Psychiatric Disorders (Keiko Iwata)....Pages 231-238 Assessment of Placental Transport Function in Studies of Disease Programming (Amanda N. Sferruzzi-Perri)....Pages 239-250 Assessment of Fatty Liver in Models of Disease Programming (Kimberley D. Bruce, Karen R. Jonscher)....Pages 251-266 Capillary Blood Sampling from the Finger (Kieron Rooney)....Pages 267-272 Physical Activity Assessment in Clinical Studies of Substance Use Disorder (Rhiannon Dowla, Bridin Murnion, Kia Roberts, Jonathan Freeston, Kieron Rooney)....Pages 273-284 Cardiopulmonary Exercise Testing (Derek Tran)....Pages 285-295 Cardiovascular Assessment in Human Research (Marjan Mosalman Haghighi, Julian Ayer)....Pages 297-310 Nutritional Programming Effects on the Immune System (Donald B. Palmer)....Pages 311-319 Small RNA Sequencing: A Technique for miRNA Profiling (Lucas Carminatti Pantaleão, Susan E. Ozanne)....Pages 321-330 Pulse-Chase Biosynthetic Radiolabeling of Pancreatic Islets to Measure Beta Cell Function (Paul C. Guest)....Pages 331-341 Rapid and Easy Protocol for Quantification of Next-Generation Sequencing Libraries (Steve F. C. Hawkins, Paul C. Guest)....Pages 343-350 Telomere Length Analysis: A Tool for Dissecting Aging Mechanisms in Developmental Programming (Jane L. Tarry-Adkins, Susan E. Ozanne)....Pages 351-363 Qualitative and Quantitative NMR Approaches in Blood Serum Lipidomics (Banny Silva Barbosa, Lucas Gelain Martins, Tássia B. B. C. Costa, Guilherme Cruz, Ljubica Tasic)....Pages 365-379 In Vivo Electrical Stimulation for the Assessment of Skeletal Muscle Contractile Function in Murine Models (Kaio F. Vitzel, Marco A. Fortes, Gabriel Nasri Marzuca-Nassr, Maria V. M. Scervino, Carlos H. Pinheiro, Leonardo R. Silveira et al.)....Pages 381-395 Experimental Model of Skeletal Muscle Laceration in Rats (Phablo Abreu, Gabriel Nasri Marzuca-Nassr, Sandro Massao Hirabara, Rui Curi)....Pages 397-401 Neuropsychiatric Sequelae of Early Nutritional Modifications: A Beginner’s Guide to Behavioral Analysis (Ann-Katrin Kraeuter, Paul C. Guest, Zoltán Sarnyai)....Pages 403-420 Hyperlocomotion Test for Assessing Behavioral Disorders (Dan Ma, Paul C. Guest)....Pages 421-425 2D-DIGE Analysis of Eye Lens Proteins as a Measure of Cataract Formation (Paul C. Guest)....Pages 427-437 Mass Spectrometry Profiling of Pituitary Glands (Divya Krishnamurthy, Hassan Rahmoune, Paul C. Guest)....Pages 439-447 Multiplex Immunoassay Profiling of Hormones Involved in Metabolic Regulation (Laurie Stephen, Paul C. Guest)....Pages 449-456 Time-Resolved Fluorescence Assays for Quantification of Insulin Precursors in Plasma and Serum (Kevin Taylor, Ian Halsall, Paul C. Guest, Keith Burling)....Pages 457-465 Identification of Neural Stem Cell Biomarkers by Isobaric Tagging for Relative and Absolute Quantitation (iTRAQ) Mass Spectrometry (Paul C. Guest)....Pages 467-476 Lab-on-a-Chip Device for Rapid Measurement of Vitamin D Levels (Harald Peter, Nikitas Bistolas, Soeren Schumacher, Cecilia Laurisch, Paul C. Guest, Ulrich Höller et al.)....Pages 477-486 Kidney Smartphone Diagnostics (P. R. Matías-García, J. L. Martinez-Hurtado)....Pages 487-498 A User-Friendly App for Blood Coagulation Disorders (Johannes Vegt, Paul C. Guest)....Pages 499-504 Hormonal Smartphone Diagnostics (P. R. Matías-García, J. L. Martinez-Hurtado, A. Beckley, M. Schmidmayr, V. Seifert-Klauss)....Pages 505-515 Back Matter ....Pages 517-520