Peptides and Peptide-based Biomaterials and their Biomedical Applications

Description

Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas. Front Matter ....Pages i-xiii Programmable Bio-surfaces for Biomedical Applications (Kiyotaka Shiba)....Pages 1-20 Solid-Binding Peptides in Biomedicine (Andrew Care, Peter L. Bergquist, Anwar Sunna)....Pages 21-36 Molecular Modelling of Peptide-Based Materials for Biomedical Applications (Tiffany R. Walsh)....Pages 37-50 Design Principles of Peptide Based Self-Assembled Nanomaterials (Rania S. Seoudi, Adam Mechler)....Pages 51-94 Bioprinting and Biofabrication with Peptide and Protein Biomaterials (Mitchell Boyd-Moss, Kate Fox, Milan Brandt, David Nisbet, Richard Williams)....Pages 95-129 Peptides as Bio-inspired Molecular Electronic Materials (John Horsley, Jingxian Yu, Yuan Qi Yeoh, Andrew Abell)....Pages 131-153 Peptide-Based Materials for Cartilage Tissue Regeneration (Nurcan Hastar, Elif Arslan, Mustafa O. Guler, Ayse B. Tekinay)....Pages 155-166 Peptides and Drug Delivery (Kavisha R. Ulapane, Brian M. Kopec, Mario E. G. Moral, Teruna J. Siahaan)....Pages 167-184 Peptide Lipidation – A Synthetic Strategy to Afford Peptide Based Therapeutics (Renata Kowalczyk, Paul W. R. Harris, Geoffrey M. Williams, Sung-Hyun Yang, Margaret A. Brimble)....Pages 185-227 Molecular Engineering of Conus Peptides as Therapeutic Leads (James T. Daniel, Richard J. Clark)....Pages 229-254 Uptake Mechanism of Cell-Penetrating Peptides (Maxime Gestin, Moataz Dowaidar, Ülo Langel)....Pages 255-264 Empowering the Potential of Cell-Penetrating Peptides for Targeted Intracellular Delivery via Molecular Self-Assembly (Yejiao Shi, João Conde, Helena S. Azevedo)....Pages 265-278 The Current Role of Cell-Penetrating Peptides in Cancer Therapy (Lucia Feni, Ines Neundorf)....Pages 279-295 Back Matter ....Pages 297-300