Genetics and Epigenetics of Breast Cancer

Description

This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment. ​ Preface Contents About the Authors 1: Breast Cancer: Epidemiology, Types, Diagnosis, and Treatment 1.1 Introduction 1.2 Epidemiology of Breast Cancer 1.3 Biomarkers in Breast Cancer 1.4 Types of Breast Cancer 1.5 Molecular Subtypes of Breast Cancer 1.6 Signs and Symptoms of Breast Cancer 1.7 Stages of Breast Cancer 1.8 Diagnosis of Breast Cancer 1.9 Treatment of Breast Cancer 1.10 Conclusion References Untitled 2: Genomic Landscape of Breast Cancer 2.1 Introduction 2.2 BRCA1 and BRCA2 2.3 Genomic Landscape of ER+ and ER- Breast Cancers 2.4 Genomic Landscape of HER2-Positive Breast Cancer 2.5 Genomic Landscape of Basal-Like and Triple-Negative Breast Cancer 2.6 Genomic Landscape of Ductal Carcinoma In Situ 2.7 Genomic Landscape of Invasive Lobular Carcinoma 2.8 Conclusion References 3: Epigenetics of Breast Cancer 3.1 Introduction 3.2 A Review of Epigenetic Modulations 3.2.1 Histone Modification 3.2.2 DNA Methylation 3.2.3 miRNA Silencing 3.2.4 Fundamental Aspects of Epigenetics of Cancer 3.3 Epigenetics of ER+ and ER- Breast Cancers 3.4 Epigenetic Landscape of HER2-Positive Breast Cancer 3.5 Epigenetic Landscape of Basal-Like and Triple Negative Breast Cancer 3.6 Epigenetic Landscape of Ductal Carcinoma In Situ 3.7 Epigenetic Landscape of Invasive Lobular Carcinoma 3.8 Conclusion References 4: Breast Cancer Therapy and Control 4.1 Introduction 4.2 Drugs Targeting Genetics and Epigenetics of Breast Cancer 4.2.1 Genetic and Epigenetic Targets for Breast Cancer Drugs 4.2.2 Conventional Drugs Targeting Genetics and Epigenetics of Breast Cancer 4.3 Problems with Conventional Therapy 4.4 Natural Remediation in Breast Cancer 4.5 Conclusion References