Covid-19 Metabolomics and Diagnosis: Volume 2

Description

This book presents a collection of chapters on Covid-19 topics, with focus on the metabolomics and diagnosis. The chapters report on diagnostic tests for detection of SARC-CoV-2 virus and related proteins as well as post-Covid omics. This book covers Fourier-Transform Infrared spectroscopy and spectromicroscopy applied to Covid-19 studies and Carbon Nanomaterials as Covid-19 Electrochemical sensors. Moreover, the reader will find content on 3D printing for virus diagnosis, as well as organ-on-a-chip models for viral infection proteomics interaction. Contents Fourier-Transform Infrared Spectroscopy and Spectromicroscopy Studies for Diagnosis of Covid-19 Infection 1 Introduction 2 Principles of Infrared Spectroscopy and Spectromicroscopy 3 FTIR for COVID-19 Studies 4 Summary References Point-of-Care Devices with Electrochemical Detection for COVID-19 Diagnosis 1 Point-of-Care Devices 2 Electrochemical Devices for SARS-CoV-2 3 Point-of-Care Electrochemical Devices for SARS-CoV-2 Detection 4 Conclusion and Future Perspectives References Carbon Nanomaterials for Electrochemical Detection of SARS-CoV-2 Infections 1 Introduction 2 Carbon Nanomaterials: Types and Classification 2.1 Carbon Nanotubes 2.2 Graphene 3 Carbon Nanomaterials in Sensing 4 COVID-19 4.1 CNMS for SARS-Cov-2 Antigen Detection 4.2 Field Effect Transistors 5 Conclusion References Use of Metallic Nanostructures in Electrochemical Biosensing of SARS-CoV-2 1 Introduction 2 Electrochemical Determination of SARS-CoV-2 with Metallic Nanostructures 3 Conclusions and Perspectives References 3D Printing for Virus Diagnosis 1 Viral Disease and Pandemics: A Brief Contextualization 2 3D Printing Technology 3 3D Printed as a New Tool in the Combat of Viral Diseases 3.1 3D Printed Accessories 3.2 3D Printing of Nasopharyngeal Swabs 3.3 RT-PCR 3.4 ELISA 4 Electrochemical 3D Printed Biosensors 4.1 Immunosensors 4.2 Genosensor 4.3 Aptasensor 5 Conclusion and Future Perspectives References Post-COVID-19 Metabolomics: Pursuing the Sequels of a Pandemic 1 Introduction 2 Biochemistry of COVID-19 Infection 2.1 Viral Entry and Replication 2.2 Physiopathology and Disease Progression 2.3 COVID-19 Infection Outside of Lungs 3 Post COVID-19 Syndrome 3.1 Post Severe COVID-19 Syndrome 3.2 Post-Mild COVID-19 Syndrome 3.3 Occurrence and Distribution of Symptoms Across Age, Race, and Sex 4 Metabolic Changes During and Post COVID-19 Infection 4.1 Plasma Metabolome Changes During COVID-19 4.2 Persistent Metabolic Changes in Post COVID-19 Syndrome References Metabolic Behavior of Covid-19 Infection Severity 1 Introduction 2 SARS-CoV-2 Infection: What You Need to Know 3 Covid-19 Severity-Related Factors 4 “Omic” Signature: An Analytical Perspective of Severity Markers 5 Conclusion References “Pandemics-on-a-Chip”: Organ-on-a-Chip Models for Studying Viral Infections 1 Introduction 2 Organ-on-Chip in the Pandemic Scenario 2.1 Microbiological Challenges for Viral Disease Research in OoC 2.2 Biofabrication of Organs-on-a-Chip for Viral Disease 3 The Study of Viral Infectious Diseases Using Organ-on-a-Chip 3.1 Gut-on-a-Chip 3.2 Lung-on-a-Chip 3.3 Kidney-on-a-Chip 3.4 Liver-on-a-Chip 4 Analytical Techniques Applied in Organ-on-a-Chip Models 4.1 Detection Methods Adapted to OoC 4.2 Methods Applied to Viruses Studies on OoC 5 Conclusions and Future Perspectives References