The Handbook of Biomarkers

Description

Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today. Front Matter....Pages i-xx Introduction....Pages 1-21 Technologies for Discovery of Biomarkers....Pages 23-72 Biomarkers and Molecular Diagnostics....Pages 73-85 Biomarkers for Drug Discovery and Development....Pages 87-113 Role of Biomarkers in Health Care....Pages 115-188 Biomarkers of Cancer....Pages 189-326 Biomarkers of Disorders of the Nervous System....Pages 327-396 Biomarkers of Cardiovascular Disorders....Pages 397-432 Biomarkers and Personalized Medicine....Pages 433-442 Regulatory Issues....Pages 443-457 Back Matter....Pages 459-492