ENGLISH

Target Identification and Validation in Drug Discovery: Methods and Protocols

By Marta Cortés-Cros , Tobias Schmelzle , Volker M. Stucke , Francesco Hofmann (auth.) , Jurgen Moll , Riccardo Colombo (eds.)

Book information

Publisher
Humana Press
Year
2013
ISBN
1627033106, 9781627033107
DOI
10.1007/978-1-62703-311-4
ISSN
1064-3745
LCC
2013931175
Language
english
Format
PDF
Filesize
5 MB (5014265 bytes)
Series
Methods in Molecular Biology 986
Edition
1
Pages
371\389
Orientation
yes
Paginated
yes
Scanned
portrait
Time added
2013-08-06 12:12:22
Pharmacology/Toxicology; Medicinal Chemistry

Description

The major reason for the elevated costs of drug development in the pharmaceutical industry is the high attrition rate. In Target Identification and Validation in Drug Discovery: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to identify and validate new target. These include methods and approaches covering biochemical, cell based, in vivo models and translational methods. Chapters also include selected case reports that demonstrate the integration of these technologies to real life experiences and to demonstrate the multiple use of more than one technology to increase knowledge on a specific target. These Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Target Identification and Validation in Drug Discovery: Methods and Protocols contains a comprehensive list of essential methods and clear protocols to follow.

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