Health Impacts of Developmental Exposure to Environmental Chemicals

Description

This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants. Front Matter ....Pages i-xi Front Matter ....Pages 1-1 Impacts of Developmental Exposure to Environmental Chemicals on Human Health with Global Perspectives (Reiko Kishi)....Pages 3-22 Front Matter ....Pages 23-23 Environmental Exposures and Adverse Pregnancy-Related Outcomes (Machiko Minatoya, Tomoyuki Hanaoka, Reiko Kishi)....Pages 25-53 Effects of Environmental Chemical Exposure on Birth Defects (Except Cryptorchidism and Hypospadias) (Tomoyuki Hanaoka, Chihiro Miyashita, Kumiko Itoh, Reiko Kishi)....Pages 55-68 Cryptorchidism and Hypospadias (Takahiko Mitsui, Fumihiro Sata, Reiko Kishi)....Pages 69-99 Endocrine-Distributing Chemicals and Reproductive Function (Atsuko Araki, Tina Kold Jensen)....Pages 101-129 Thyroid Hormone System and Development (Sachiko Itoh)....Pages 131-152 Neurodevelopment and Neurobehavioral Disorders in Relation to Developmental Exposures (Youssef Oulhote, David C. Bellinger)....Pages 153-174 Immunotoxicity: Impacts and Research Approaches (Carsten Heilmann, Philippe Grandjean)....Pages 175-190 Long-Term Implications of Developmental Programming and Obesity (Jerrold J. Heindel)....Pages 191-220 Front Matter ....Pages 221-221 Impact of Air Pollution Hazards on Human Development (Eunhee Ha)....Pages 223-245 Mercury, Lead, Manganese, and Hazardous Metals (Ching-Chung Lin, Meng-Shan Tsai, Mei-Huei Chen, Pau-Chung Chen)....Pages 247-277 Environmental Pollution and Recent Data on Asian Children’s Health in Relation to Pre- and Early Post-natal Exposure to Persistent Organic Pollutants, Including PCBs, PCDD/PCDFs, and Organochlorine Pesticides (Chihiro Miyashita)....Pages 279-300 Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring (Houman Goudarzi, Keiko Yamazaki)....Pages 301-357 Brominated Flame Retardants (BFRs) (Kyungho Choi, Sunmi Kim)....Pages 359-373 Phthalates (Hui-Ju Wen, Han-Bin Huang, Tsung-Lin Tsai, Shu-Li Wang)....Pages 375-404 Bisphenols and Alkylphenols (Mei-Lien Chen, Chia-Huang Chang, Machiko Minatoya)....Pages 405-437 Front Matter ....Pages 439-439 Adverse Outcome Pathways for Developmental Toxicity (John M. Rogers)....Pages 441-462 Exposomics: The Exposome in Early Life (Léa Maitre, Martine Vrijheid)....Pages 463-484 Gene–Environment Interactions to Detect Adverse Health Effects on the Next Generation (Fumihiro Sata, Sumitaka Kobayashi, Reiko Kishi)....Pages 485-512 Epigenetics: Strategies for Prevention Research (Wilfried Karmaus, Ali H. Ziyab, Nandini Mukherjee)....Pages 513-529 From Research to Intervention (Philippe Grandjean)....Pages 531-542 Front Matter ....Pages 543-543 Further Direction of Research and Policy Making of Environment and Children’s Health (Reiko Kishi, Atsuko Araki)....Pages 545-557