In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

Description

This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials. With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers. Front Matter ....Pages i-vi The Role of In Vivo Screening Studies in Assessing Manufactured Nanomaterials (Robert Landsiedel, Masashi Gamo, Akihiko Hirose)....Pages 1-21 Front Matter ....Pages 23-23 The Short-Term Inhalation Study (STIS) as a Range Finder and Screening Tool in a Tiered Grouping Strategy (Karin Wiench, Lan Ma-Hock)....Pages 25-65 Use of Short-Term Inhalation Study to Obtain Initial Hazard Data and Prepare for Subacute and Subchronic Inhalation Studies, and Toxicokinetic Studies (Ki Soo Jeon, Jae Seong Yi, Il Je Yu)....Pages 67-77 Subchronic Inhalation Toxicity Study with a Vapor-Grown Carbon Nanofiber in Male and Female Rats (OECD 413): Does Nanofiber Exposure Have Adverse Impacts on the Cardiovascular System? (David B. Warheit)....Pages 79-91 Front Matter ....Pages 93-93 Comparison of Responses in Rat Lung Following Inhalation and Intratracheal Administration of Nanoparticles (Yukiko Yoshiura, Yuri Fujisawa, Taisuke Tomonaga, Hiroto Izumi, Takako Oyabu, Toshihiko Myojo et al.)....Pages 95-105 Standardization of Intratracheal Instillation Study of Manufactured Nanomaterials (Toshio Kobayashi, Yutaka Oshima, Yasuhiro Tsubokura, Takakazu Kayashima, Makoto Nakai, Nobuya Imatanaka et al.)....Pages 107-122 Sample Preparation and the Characterization for Intratracheal Administration (Kenji Kawaguchi, Kenji Koga, Takeshi Sasaki)....Pages 123-144 Development of Intratracheal Intrapulmonary Spraying (TIPS) Administration as a Feasible Assay Method for Testing the Toxicity and Carcinogenic Potential of Multiwall Carbon Nanotubes (Hiroyuki Tsuda, David B. Alexander)....Pages 145-163 Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study Using Intratracheal Administration (Yutaka Oshima, Toshio Kobayashi, Takakazu Kayashima, Makoto Nakai, Nobuya Imatanaka)....Pages 165-192 Toxicokinetics of Nano Materials After the Intratracheal Administration (Naohide Shinohara)....Pages 193-205 In Vitro Alveolar Epithelial Models Toward the Prediction of Toxicity and Translocation of Nanoparticles: A Complementary Method for Mechanism Analyses in Humans (Kikuo Komori, Kokoro Iwasawa, Rie Ogasawara, Akira Suwabe, Yasuyuki Sakai)....Pages 207-223