Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management

Description

Chronic lymphocytic leukemia (CLL) is the second most frequently encountered leukemia in North America and Europe, and the object of considerable research and treatment. In Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management, prominent physicians and researchers from the leading medical centers in the United States and Europe critically review the latest scientific advances in our understanding of the molecular genetics and biology of CLL and apply them to its best management. Their comprehensive reviews of the clinical aspects of CLL focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogeneic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several promising new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed. Cutting-edge and clinically focused, Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management offers today's hematologists and oncologists the opportunity to update their clinical knowledge and sort out the range of available therapies to provide optimal patient care. Front Matter....Pages i-xiv Front Matter....Pages 1-1 The Natural History of CLL....Pages 3-54 Front Matter....Pages 55-55 Genetics of B-Cell Chronic Lymphocytic Leukemia....Pages 57-75 Molecular Biology of Chronic Lymphocytic Leukemia....Pages 77-94 The Heterogeneous Origin of the B-CLL Cell....Pages 95-107 Pathogenesis of Impaired Cellular Immune Function in CLL....Pages 109-121 Cytokines and Soluble Molecules in CLL....Pages 123-142 Front Matter....Pages 143-143 Immunophenotypic Differential Diagnosis and Cell Cycle Analysis....Pages 145-161 Common Cytogenetic Abnormalities....Pages 163-171 Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia....Pages 173-190 Front Matter....Pages 191-191 Staging of Chronic Lymphocytic Leukemia....Pages 193-199 Prognostic Indicators of Chronic Lymphocytic Leukemia....Pages 201-215 Front Matter....Pages 217-217 Guidelines for Clinical Management of CLL....Pages 219-240 Chemotherapy of Chronic Lymphocytic Leukemia....Pages 241-254 Autologous and Allogeneic Transplantations for Chronic Lymphocytic Leukemia....Pages 255-268 Monoclonal Antibody Therapy in Chronic Lymphocytic Leukemia....Pages 269-298 Immunotoxin Therapy of Chronic Lymphocytic Leukemia....Pages 299-314 New Treatment Strategies in Chronic Lymphocytic Leukemia....Pages 315-328 Gene Therapy of Chronic Lymphocytic Leukemia....Pages 329-340 Front Matter....Pages 341-341 Infections in Patients With Chronic Lymphocytic Leukemia....Pages 343-359 Autoimmune and Hypersplenic Cytopenias....Pages 361-376 Front Matter....Pages 341-341 Clonal Evolution and Second Malignancies in B-CLL....Pages 377-386 Front Matter....Pages 387-387 Inherited Predisposition to Chronic Lymphocytic Leukemia....Pages 389-400 Young Patients With Chronic Lymphocytic Leukemia....Pages 401-413 Back Matter....Pages 415-421