Tuberculosis Host-Pathogen Interactions

Description

This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery. Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections. Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions. Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide. Front Matter ....Pages i-viii Cell Wall Biosynthesis and Latency During Tuberculosis Infections (Michio Kurosu)....Pages 1-21 The Silent Plague: Regulation of Latent Tuberculosis Infections (Parnia Behinaein, Jeffrey D. Cirillo)....Pages 23-42 Trehalose Dimycolate (Cord Factor) as a Contributing Factor to Tuberculosis Pathogenesis (Jeffrey K. Actor)....Pages 43-61 Role of Myeloid-Derived Suppressor Cells and Regulatory T-Cells in the Tuberculous Granuloma (Laurene S. Cheung, Geetha Srikrishna, William R. Bishai)....Pages 63-93 Interactions of Mycobacterium tuberculosis with Human Mesenchymal Stem Cells (Arshad Khan, Chinnaswamy Jagannath)....Pages 95-111 Role of Mycobacterium tuberculosis PE and PPE Proteins in Pathogen-Host Interactions (Govardhan Rathnaiah, Denise K. Zinniel, Raul G. Barletta)....Pages 113-121 Co-Infection with TB and HIV: Converging Epidemics, Clinical Challenges, and Microbial Synergy (Matthew B. Huante, Rebecca J. Nusbaum, Janice J. Endsley)....Pages 123-153 Optical In Vivo Imaging in Tuberculosis Research (Riti Sharan, Thushara Galbadage, Panatda Saenkham, Madeleine Moule, Preeti Sule, Ying Kong et al.)....Pages 155-200 Mycobacteria Infection and Lipid Droplets: Host and Pathogen Stealing, Sharing and Storing Fat (Richard M. Armstrong, Thomas C. Zahrt)....Pages 201-229 Potential Immunology, Transcriptomics and Epigenomic Prediction Tools of the Future to Improve tuberculosis Control (Andrew DiNardo, Anna M. Mandalakas)....Pages 231-249 Back Matter ....Pages 251-255