Type IV Secretion in Gram-Negative and Gram-Positive Bacteria

Description

Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells. This volume summarizes our current knowledge of the large variety and structural diversity of T4SSs in pathogenic Escherichia, Agrobacterium, Legionella, Coxiella, Bartonella, Helicobacter, Enterococcus and other species. Divided into 13 chapters contributed by leading experts, it presents findings that significantly enhance our understanding of how various pathogens manipulate host cell functions to trigger bacterial uptake, promote intracellular growth, suppress defense mechanisms and of how bacteria spread antibiotic resistances, thus facilitating bacterial colonization and disease development. The book is an invaluable source of information for researchers and clinicians. Front Matter ....Pages i-xxii Biological Diversity and Evolution of Type IV Secretion Systems (Peter J. Christie, Laura Gomez Valero, Carmen Buchrieser)....Pages 1-30 Structural and Molecular Biology of Type IV Secretion Systems (Célia Bergé, Gabriel Waksman, Laurent Terradot)....Pages 31-60 Prokaryotic Information Games: How and When to Take up and Secrete DNA (Kerstin Stingl, Günther Koraimann)....Pages 61-92 Relaxases and Plasmid Transfer in Gram-Negative Bacteria (Ellen L. Zechner, Gabriel Moncalián, Fernando de la Cruz)....Pages 93-113 Mechanisms of Conjugative Transfer and Type IV Secretion-Mediated Effector Transport in Gram-Positive Bacteria (Elisabeth Grohmann, Walter Keller, Günther Muth)....Pages 115-141 Coupling Proteins in Type IV Secretion (Matxalen Llosa, Itziar Alkorta)....Pages 143-168 Type IV Secretion in Agrobacterium tumefaciens and Development of Specific Inhibitors (Mahzad Sharifahmadian, Christian Baron)....Pages 169-186 The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling (Steffen Backert, Rainer Haas, Markus Gerhard, Michael Naumann)....Pages 187-220 Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System (Hubert Hilbi, Hiroki Nagai, Tomoko Kubori, Craig R. Roy)....Pages 221-242 Beginning to Understand the Role of the Type IV Secretion System Effector Proteins in Coxiella burnetii Pathogenesis (Anja Lührmann, Hayley J. Newton, Matteo Bonazzi)....Pages 243-268 Type IV Effector Secretion and Subversion of Host Functions by Bartonella and Brucella Species (Christoph Dehio, Renée M. Tsolis)....Pages 269-295 Role and Function of the Type IV Secretion System in Anaplasma and Ehrlichia Species (Yasuko Rikihisa)....Pages 297-321 Secretion of Chromosomal DNA by the Neisseria gonorrhoeae Type IV Secretion System (Melanie M. Callaghan, Jan-Hendrik Heilers, Chris van der Does, Joseph P. Dillard)....Pages 323-345 Erratum to: Type IV Secretion in Gram-Negative and Gram-Positive Bacteria (Steffen Backert, Elisabeth Grohmann)....Pages E1-E1