ENGLISH

RNP Particles, Splicing and Autoimmune Diseases

By Frank Jung , Constantin E. Sekeris (auth.) , Dr. Johannes Schenkel (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1998
ISBN
978-3-642-48975-4, 978-3-642-80356-7
DOI
10.1007/978-3-642-80356-7
Language
english
Format
PDF
Filesize
6 MB (6161110 bytes)
Series
Springer Lab Manual
Edition
1
Pages
225\233
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Cell Biology; Biochemistrygeneral; Molecular Medicine

Description

The maturation of the precursors of mRNA to a functional transcript in eukaryotic cells is a complex, multistep process. It includes the formation of RNP complexes and the splicing procedure. Also, the presence of snRNA packaged as snRNP particles plays an important role in this process. In addition, snRNPs are involved in various autoimmune diseases in which autoantibodies are directed against components of these particles. Relevant techniques to investigate RNA processing, splicing, protein-RNA complex formation and protein-RNA interactions as well as the use of autoantibodies in basic and clinical research are presented in this manual.

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