ENGLISH

Protein Modules in Signal Transduction

By B. J. Mayer , R. Gupta (auth.) , Professor Anthony J. Pawson FRS (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1998
ISBN
978-3-642-80483-0, 978-3-642-80481-6
DOI
10.1007/978-3-642-80481-6
Language
english
Format
PDF
Filesize
12 MB (12834351 bytes)
Series
Current Topics in Microbiology and Immunology 228
Edition
1
Pages
368\374
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Cell Biology; Biochemistrygeneral; Molecular Medicine

Description

The external signals that control cellular behavior are chanelled through cell surface receptors, that in turn regulate cytoplasmic signaling pathways. Work over the last ten years has indicated that the activation of these intra- cellular signaling pathways depends on a series of protein-protein and protein-phospholipid interactions mediated by modular polypeptide domains. Through their association with specific peptide motifs, these protein modules define a recognition code through which many aspects of cellular function are controlled. The articles in this book describe the varied features of these domains, and outline the structural, biochemical and genetic evidence that demonstrates their importance in co-ordinating cellular responses to external cues.

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