ENGLISH

Genomic Clinical Trials and Predictive Medicine

By Richard M. Simon

Book information

Publisher
Cambridge University Press
Year
2013
ISBN
9781107306349, 9781107008809
LCC
R853.C55 G46 2013
Language
english
Format
PDF
Filesize
2 MB (2484879 bytes)
Series
Practical Guides to Biostatistics and Epidemiology Ser.
Pages
160\160
Time added
2023-08-04 06:45:48
Genomics -- Statistical methods. ; Clinical trialsPreventive.

Description

Genomics is majorly impacting therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying which patients are most likely to benefit from each treatment. It is oriented to both clinical investigators and statisticians. For clinical investigators, it includes background information on clinical trial design and statistical analysis. For statisticians and others who want to go deeper, it covers state-of-the-art adaptive designs and the development and validation of probabilistic classifiers. The author describes the development and validation of prognostic and predictive biomarkers and their integration into clinical trials that establish their clinical utility for informing treatment decisions for future patients.

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