ENGLISH

Electric Field-Induced Effects on Neuronal Cell Biology Accompanying Dielectrophoretic Trapping

By Dr. Tjitske Heida (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2003
ISBN
978-3-540-00637-4, 978-3-642-55469-8
DOI
10.1007/978-3-642-55469-8
Language
english
Format
PDF
Filesize
2 MB (1781007 bytes)
Series
Advances in Anatomy, Embryology and Cell Biology 173
Edition
1
Pages
80\86
Time added
2013-12-12 02:00:00
Neurosciences

Description

The concept of the cultured neuron probe was induced by the possible selective stimulation of nerves for functional recovery after a neural lesion or disease. The probe consists of a micro-electrode array on top of which groups of neuronal cells are cultured. An efficient method to position groups of neuronal cells on top of the stimulation sites of the micro-electrode array is developed. With negative dielectrophoretic forces, produced by non-uniform electric fields on polarizable particles, neuronal cells are trapped. Experimental results and model simulations describe the trapping process and its effect on neuronal cell viability.

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