ENGLISH

Handbook of Neurochemistry and Molecular Neurobiology: Neuroimmunology

By Abel Lajtha , Armen Galoyan , H. O. Besedovsky , A. del Rey (auth.) , Hugo O. Besedovsky (eds.)

Book information

Publisher
Springer US
Year
2008
ISBN
9780387303581, 9780387303987
Language
english
Format
PDF
Filesize
6 MB (6016938 bytes)
Series
Springer Reference
Edition
3
Pages
495\491
Time added
2020-08-30 06:11:09
Neurosciences

Description

This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain. Front Matter....Pages i-x Back Matter....Pages 3-17 ....Pages 19-35

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