HSP70 in Human Diseases and Disorders

Description

The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders. Using an integrative approach to expand our current understanding of HSP70 functions, the contributors provide a synopsis of novel mechanisms by which HSP70 is involved in the regulation of human diseases and disorders. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology. Front Matter ....Pages i-ix Front Matter ....Pages 1-1 Heat Shock Protein 70 and Molecular Confession During Neurodegeneration (Komal Panchal, Ajay Kumar, Anand K. Tiwari)....Pages 3-35 Hsp70-Family Proteins and Neurodegenerative Diseases (Zheying Sun, Roy J. Blackburn, Laura J. Blair, John Koren III)....Pages 37-55 Heat Shock Protein70 in Neurological Disease (Pinar Ortan, Ozden Yildirim Akan, Ferda Hosgorler)....Pages 57-69 Involvement of Heat Shock Protein 70 (Hsp70) in Gastrointestinal Cancers (Dipamoy Datta, Suparna Banerjee, Anupama Ghosh, Soumyajit Banerjee Mustafi, Prosenjit Sen, Sanghamitra Raha)....Pages 71-91 Heat Shock Protein 70 and Cancer (Tuoen Liu, Shousong Cao)....Pages 93-111 Implication of HSP70 in the Pathogenesis of Gastric Cancer (Prakash Chand Sharma, Renu Verma)....Pages 113-130 Front Matter ....Pages 131-131 Double Face of eHsp70 in Front of Different Situations (Maria M. Barreca, Fabiana Geraci)....Pages 133-161 HSP70 Is a Major Contributor to the MHCII Ligandome and Inducer of Regulatory T Cells (Willem van Eden, Femke Broere, Ruurd van der Zee)....Pages 163-171 Immune Properties of HSP70 (Yves Delneste, Vincent Larochette, Pascale Jeannin)....Pages 173-203 Molecular Chaperones Regulating the Dynamics, Composition and Functionality of RNP Granules: Implications for Age-Related Diseases (Daniel Mateju, Laura Mediani, Federica F. Morelli, Simon Alberti, Serena Carra)....Pages 205-222 Heat Shock Proteins in Cardiovascular Diseases: From Bench to Bedside (Francesca Bonomini, Gaia Favero, Valentina Trapletti, Rita Rezzani)....Pages 223-245 Clinical Implication of Heat Shock Protein 70 in Kidney Disease (Alev Yilmaz, Zeynep Nagehan Yuruk Yildirim)....Pages 247-260 Heat Shock Proteins in the Kidney: What Is Known About Their Role in Kidney Disease (Shobhana Nayak Rao)....Pages 261-271 Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina (Ting Zhang, Bobak Bahrami, Ling Zhu)....Pages 273-287 Front Matter ....Pages 289-289 Emerging Role of HSP70 in Human Diseases (Anjali Garg, Bandana Kumari, Manish Kumar)....Pages 291-304 Intranasal Administration of Hsp70: Molecular and Therapeutic Consequences (Michael B. Evgen’ev, David G. Garbuz, Alexei V. Morozov, Natalia V. Bobkova)....Pages 305-323 The Effectiveness of Antitumor Vaccine Enriched with a Heat Shock Protein 70 (Gennadiy Didenko, Olena Kruts, Larysa Skivka, Yuriy Prylutskyy)....Pages 325-345 Mammalian Heat Shock Protein Hsp105: The Hsp70 Inducer and a Potent Target for Cancer Therapy (Youhei Saito, Yuji Nakayama)....Pages 347-359 Suppression of HSP70 Expression by Quercetin and Its Therapeutic Potential Against Cancer (Evren Önay Uçar, Aslıhan Şengelen, Elif Mertoğlu, Murat Pekmez, Nazlı Arda)....Pages 361-379 Hsp70 in Fungi: Evolution, Function and Vaccine Candidate (Shraddha Tiwari, Jata Shankar)....Pages 381-400 Back Matter ....Pages 401-403