Heat Shock Proteins in Signaling Pathways

Description

Signaling pathways is a comprehensive mechanism by which all cellular organisms communicate internally and externally with their microenvironment. This is a highly complex and exact process. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. Knowledge gained from the better understanding of signaling pathways will help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Heat shock proteins (HSP) are uniquely involved in a number of critical signaling pathways. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery. Front Matter ....Pages i-xi Front Matter ....Pages 1-1 Thiol-Based Redox Signaling: Impacts on Molecular Chaperones and Cellular Proteostasis (Amy E. Ford, Kevin A. Morano)....Pages 3-22 Heat Shock Proteins (HSP) in Stress-Related Inflammatory Diseases (Burcu Hasdemir, Dina Shakran, Sreenivasan Paruthiyil, Aditi Bhargava)....Pages 23-40 Heat Shock Response and Metabolism in Skeletal Muscle (Yuki Tamura)....Pages 41-52 Temperature Stress and Redox Homeostasis: The Synergistic Network of Redox and Chaperone System in Response to Stress in Plants (Hui-Chen Wu, Florence Vignols, Tsung-Luo Jinn)....Pages 53-90 Dynamics of Heat Shock Proteins in Immunity and Aging (Udayakumar Prithika, Krishnaswamy Balamurugan)....Pages 91-100 Heat Shock Proteins, Exercise and Inflammation (Fabiano T. Amorim, Micah N. Zuhl)....Pages 101-119 Heat Shock Proteins and Alarmins in Autoimmunity (Anil K. Chauhan)....Pages 121-137 HO-1/HSP32 and Cardiac Stress Signaling (Lakshmikanthan Panneerselvam, Azhwar Raghunath, Kiruthika Sundarraj, Ekambaram Perumal)....Pages 139-159 Role of Heat Shock Protein 90 in Regulating Downstream Signal Transduction Cascades (Wei Lei, David Duron, Carrie Stine, John M. Streicher)....Pages 161-182 Diverse Roles of Heat Shock Proteins in Immune Activation and Tolerance: A Comprehensive Review of Mechanisms and Therapeutic Relevance (Anjali Ramaswamy, Ping Wei, Fan Pan)....Pages 183-215 Cytosolic Heat Shock Protein 90 in Plant Hormone and Environmental Stress Response (Kenji Yamada, Etsuko Watanabe)....Pages 217-230 Front Matter ....Pages 231-231 Targeting Heat Shock Proteins in Multiple Myeloma (Vijay P. Kale, Sangita Phadtare, Shantu G. Amin, Manoj K. Pandey)....Pages 233-251 IER5 Is a p53-Regulated Activator of HSF1 That Contributes to Promotion of Cancer (Tatsuya Kawase, Yu Chen, Rieko Ohki)....Pages 253-272 Heat Shock Proteins in Digestive Tract Cancer: Molecular Mechanism and Therapeutic Potential (Liang Wenjin, Li Zeming, Liao Yong, Wang Yan, Tang Bo)....Pages 273-287 Extracellular HSP90α Versus Intracellular HSP90β in Wound Healing and Cancer (Vadim Lincoln, Xin Tang, Mei Chen, Wei Li)....Pages 289-315 Regulation of Calcineurin Signaling Through Blocking of the Chaperone Function of Hsp90 by HDAC Inhibitors (Yoichi Imai, Arinobu Tojo)....Pages 317-328 Signaling Functions of Extracellular Hsp90 (eHsp90) in Cancer Metastasis (Aaron S. Bernstein, Daniel G. Jay)....Pages 329-344 Role of the Molecular Chaperones Hsp70 and Hsp90 in the DNA Damage Response (Laura E. Knighton, Andrew W. Truman)....Pages 345-358 Heat Shock Protein 90 Inhibitors in Lung Cancer Therapy (Suman Chatterjee, Timothy F. Burns)....Pages 359-395 HSP90 Inhibitors Blocking Multiple Oncogenic Signaling Pathways for the Treatment of Cancer (Fen Jiang, Xiao-Li Xu, Qi-Dong You)....Pages 397-429 Front Matter ....Pages 431-431 Heat Shock Proteins Involved in Neuromuscular Pathologies (Candelaria Merino-Jiménez, César García-Cruz, Jorge Aragón, Lourdes Siqueiros-Márquez, Cecilia Montañez)....Pages 433-458 Heat Shock Proteins in Neural Signaling: Implications in Health and Disease (Pooja-Shree Mishra, Aditi Singh)....Pages 459-478 Back Matter ....Pages 479-482