Neurotoxicité de deux pesticides (Acetamipride et Deltamethrine) et la prévention de cette toxicité par la quercétine chez le rat

Description

Effects of Deltamethrin on striatum and hippocampus mitochondrial integrity and the protective role of Quercetin in rats Abstract Introduction Material and methods Animals Chemical and exposure protocol Behavioral testing Open field Classical labyrinth test Sucrose test (anhedonia test) MWM Sacrifice of animals and brain removal Tissue and regional cytosolic fraction preparation Isolation of brain mitochondria and matrix preparation Evaluation of swelling, permeability, and mitochondrial respiration Determination of carbohydrate, protein, and lipid levels Determination of glutathione and malondialdehyde acid levels Determination of GST, GPx, CAT, and SOD activities Determination of cytochrome c and caspase 3 activities AchE activity Histological study Data processing and statistical test Results Study of mitochondrial metabolic parameters Mitochondrial stress parameter testing Study of mitochondrial apoptosis parameters Behavioral study Histological study Discussion References Alteration... Abstract Introduction Materials and methods Chemicals Animal treatments Sacrifice of the animals and brain extraction Brain mitochondria isolation and matrix preparation Assessment of redox status markers in brain mitochondria Evaluation of swelling, permeability, and mitochondrial respiration Data analysis Results Oxidative stress status of matrix mitochondria Evaluation of swelling, permeability, and mitochondrial respiration Discussion Conclusion References