Alternate Fractionation in Radiotherapy: Paradigm Change

Description

This book, written by leading international experts, describes alternate fractionation strategies in which technology-driven precise targeting and dosing allow for improved conformance and decreased volumes, with concordant lessening of toxicity, reduction in treatment time, and lower overall health care expense. The aim is to provide the advanced clinician with an up-to-date evidence-based reference that will assist in the delivery of enhanced patient care in daily practice. Traditional multi-week fractionation schedules were established at a time when the inclusion of relatively large amounts of normal tissue was unavoidable owing to the lack of accurate target localization during treatment. Such schedules are time and resource consuming, difficult for patients, and expensive. Nevertheless, acceptance of alternate fractionation strategies has been slow in some countries. The paradigm is, however, changing as evidence accumulates to demonstrate improved local control, equivalence of tolerance, or both. In documenting these alternate strategies, this book will be of value for radiation oncologists, medical physicists, and oncologists worldwide. Front Matter ....Pages i-xii Introduction (Theodore E. Yaeger, Paolo Montemaggi, Mark Trombetta, Jean-Philippe Pignol, Luther Brady)....Pages 1-4 The Radiobiological Aspects of Altered Fractionation (Alan E. Nahum, Richard P. Hill)....Pages 5-19 Technological Advance Enabling Alternate Fractionation (Olivier Gayou)....Pages 21-30 Workflow and Quality Assurance in Altered Fractionation (Geoffrey S. Ibbott)....Pages 31-39 The Future of Altered Fractionation (Brian J. Gebhardt, Zachary D. Horne, Sushil Beriwal)....Pages 41-63 Brachytherapy: The Original Altered Fractionation (Mark Trombetta, Janusz Skowronek)....Pages 65-73 Front Matter ....Pages 75-75 Altered Fractionation in Radiotherapy of CNS Tumors (John C. Flickinger)....Pages 77-89 Head and Neck Cancer (Olgun Elicin, E. Mahmut Ozsahin)....Pages 91-126 Whole-Breast Hypofractionated Radiotherapy (Fernand Missohou, Mark Trombetta, Jean-Philippe Pignol)....Pages 127-139 Accelerated Partial Breast Irradiation (Jean-Philippe Pignol, Nienke Hoekstra, Fernand Missohou, Mark Trombetta)....Pages 141-155 Lung Cancer (Mauro Loi, J.J. Nuyttens)....Pages 157-172 Alternate Fractionation for Hepatic Tumors (Alejandra Méndez Romero, Thomas B. Brunner, Alexander V. Kirichenko, Wolfgang A. Tomé, Yun Liang, Nathan Ogden et al.)....Pages 173-201 Stereotactic Body Radiotherapy with Functional Treatment Planning in Hepatocellular Carcinoma (Alexander Kirichenko, Eugene J. Koay, Shaakir Hasan, Christopher Crane)....Pages 203-210 Gastrointestinal Cancer: Pancreas (Linda Chen, Lauren M. Rosati, Joseph M. Herman)....Pages 211-227 Hypofractionation in Patients with Rectal Cancer (Te Vuong, Slobodan Devic, Krzysztof Bujko)....Pages 229-239 Hypofractionated Radiotherapy in Genitourinary Cancer: Better with Less (Ruud C. Wortel, Luca Incrocci)....Pages 241-256 Fractionation Regimens for Gynecologic Malignancies (Joanne Jang, Patrizia Guerrieri, Akila N. Viswanathan)....Pages 257-272 Skin: The Case for Altered Fractionation in the Treatment of Both Malignant and Benign Conditions (James Fontanesi, Brian Kopitzki, Richard Zekman)....Pages 273-305 Radiotherapy for Primary and Metastatic Soft Tissue Sarcomas: Altered Fraction Regimens with External Beam and Brachytherapy (Sara Alcorn, Stephanie Terezakis)....Pages 307-321 Stereotactic Body Radiotherapy (Gargi Kothari, Simon S. Lo, Matthew Foote, Arjun Sahgal, Irene Karam, Michael Lock et al.)....Pages 323-395 Altered Fraction Radiotherapy in Palliation (Srinivas Raman, Natalie Logie, Joshua Jones, Eric Chang, Steven Lutz, Edward Chow)....Pages 397-418 Erratum to: The Radiobiological Aspects of Altered Fractionation (Alan E. Nahum, Richard P. Hill)....Pages 419-419 Back Matter ....Pages 421-432