Stereotactic Radiosurgery for Prostate Cancer

Description

This book offers a comprehensive evaluation of the use of stereotactic body radiosurgery (SBRT) for the treatment of prostate cancer. The rationale, selection criteria, and treatment planning for prostate SBRT are explained. Important imaging and anatomic considerations are discussed, and detailed consideration devoted to organ motion and tumor tracking during SBRT. Outcomes of therapy are then examined, with thorough appraisal of side effect profiles and quality of life impacts. Clear guidance is provided on how to deliver the therapy in a way that minimizes the risk of long-term urinary and rectal toxicities. Stereotactic radiosurgery for prostate cancer is an increasingly used form of treatment. Retrospective investigations have demonstrated the safe application of high-dose treatments, with 5-year results comparable to those achieved with protracted external beam radiotherapy. Prospective studies are underway comparing SBRT with more traditional forms of image-guided and intensity-modulated radiotherapy. In offering in-depth guidance on safe delivery of prostate SBRT, this book will be of value for students of radiation oncology, more experienced practitioners, and medical physicists. Front Matter ....Pages i-viii Optimizing Selection of Patients for Prostate SBRT: Overview of Toxicity and Efficacy in Low, Intermediate, and High-Risk Prostate Cancer (Amar U. Kishan, Christopher R. King)....Pages 1-16 Treatment Planning Considerations for Prostate SBRT and MRI Based Planning (Neelam Tyagi, Margie Hunt)....Pages 17-41 Organ Motion Considerations and Tracking During Prostate SBRT (Laura Happersett, D. Michael Lovelock)....Pages 43-53 Imaging and Anatomic Considerations for Prostate and Pelvic Organs Contouring (Tomer Charas, Alberto Vargas, Michael J. Zelefsky)....Pages 55-73 Using Imaging to Design Dose Volume Constraints for Target and Normal Tissue to Reduce Toxicity (Rosario Mazzola, Filippo Alongi)....Pages 75-83 Expected PSA and Biochemical Control with Prostate SBRT Compared to Conventional Fractionated Radiotherapy (Josephine Kang, Alan Katz)....Pages 85-92 Overview of Tumor Control Outcomes with Prostate SBRT for Low and Intermediate Risk Prostate Cancer and Comparison to Other Treatment Interventions (Amandeep S. Taggar, Paveen Mann, Michael J. Zelefsky)....Pages 93-110 Overview of Toxicity Outcomes with Prostate SBRT and Comparison to Other Treatment Interventions (Urinary, Rectal and Sexual Outcomes) (Michael C. Repka, Simeng Suy, Shaan K. Kataria, Thomas P. Kole, Ima Paydar, Brian T. Collins et al.)....Pages 111-127 Quality of Life Outcomes After SBRT (Thomas Zilli, Raymond Miralbell)....Pages 129-139 Techniques for Reducing Toxicity After SBRT (Daniel Gorovets, Marisa Kollmeier, Michael J. Zelefsky)....Pages 141-151 SBRT for High-Risk Prostate Cancer (Alejandro González-Motta, Mekhail Anwar, Alexander Gottschalk, Martina Descovich, Mack Roach III)....Pages 153-169 Salvage SBRT for Local Recurrence of Prostate Cancer After Definitive Radiotherapy (Daniel Lam Cham Kee, Jérôme Doyen, Alexander T. Falk, Jean-Michel Hannoun-Levi)....Pages 171-182 Dose Escalation for Prostate Cancer Using Oligofractionated, Stereotactic Ablative Radiotherapy (Michael R. Folkert, Robert D. Timmerman)....Pages 183-196 Summary of Ongoing Prospective Trials Using SBRT for Prostate Cancer (Kirsty Morrison, Nicholas van As)....Pages 197-215 Conclusions: Perspectives on the Role of SBRT in the Management of Localized Prostate Cancer (Michael J. Zelefsky)....Pages 217-219