Pathology of Graft vs. Host Disease: A Case Based Teaching Guide

Description

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, pathologists and researchers with an interest in GVHD and its mimickers. The book reviews new data about risk factors affecting outcomes, pathologic features, and profiles the new WHO guidelines as well as current practices. The richly illustrated text covers the gamut of gross and histologic presentations of acute GVHD in skin, gut, liver, and additional organs affected by chronic GVHD. An engaging aspect of this book is the format of patient based cases as the focus for the major chapters teaching points. The case presentations include both infectious and toxic complications that mimic GVHD, or displaying similar morphologies. Recent up to date references on clinical investigations and pathogenesis make the reading and teaching resonant with the readers. Pathology of Graft vs. Host Disease will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging disease. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters were written by experienced transplant physicians with expertise in their fields. Front Matter ....Pages i-xi The Contributions of Pathology to the Diagnosis and Management of GVHD: Caveats and Lessons Learned (Howard M. Shulman)....Pages 1-10 Evolutions in the Clinical Management of GVHD (Cecilia C. S. Yeung, H. Joachim Deeg)....Pages 11-20 Early GVHD with Follicular Rash (Cecilia C. S. Yeung, Thanh T. Dinh, Howard M. Shulman)....Pages 21-34 The Basic Sequence of Injury in Acute Skin GVHD (Teresa S. Hyun, Shiva Khoobyari, Oliver H. Chang)....Pages 35-45 Leukemia Cutis and Hematologic Malignancies with Cutaneous Manifestation (Adam James Robin, Cecilia C. S. Yeung)....Pages 47-54 Lichenoid Inflammatory Phase of Chronic Skin GVHD (Oliver H. Chang, Marie E. Perrone, Adam James Robin, Howard M. Shulman)....Pages 55-68 Cutaneous Chronic GVHD: Sclerodermatous and Morpheic Variants (Teresa S. Hyun, Howard M. Shulman)....Pages 69-83 Early Changes of Gut GVHD: Differential Diagnosis and Criteria for Crypt Cell Apoptosis (Cecilia C. S. Yeung, David W. Woolston, Howard M. Shulman)....Pages 85-95 Persistent Gastrointestinal GVHD: The Application and Utility of Histologic Grading Schemes (Howard M. Shulman, David W. Woolston, David Myerson)....Pages 97-111 Pathobiology of Fatal Gastrointestinal GVHD (Howard M. Shulman, David W. Woolston)....Pages 113-128 Abdominal Pain and Diarrhea When It Is Not GVHD (David Myerson, Sahl Ali)....Pages 129-142 Mucosal Chronic GVHD Affecting the Oral Pharyngeal, Esophageal, and Anogenital Regions (Howard M. Shulman, David M. Hockenbery, Cecilia C. S. Yeung)....Pages 143-156 Pre-transplant Liver Disorders: Post-transplant Impact on Developing Venocclusive Disease/Sinusoidal Obstruction Syndrome and Other Hepatic Problems (Howard M. Shulman)....Pages 157-168 The Pathological Spectrum of Hepatic GVHD (Keith R. Loeb, David W. Woolston, Howard M. Shulman)....Pages 169-183 Rapidly Progressing Cholestatic Liver Failure After Allogeneic Stem Cell Transplant from Hepatitis C Virus-Positive Donor (FCHCV) (Keith R. Loeb, Howard M. Shulman)....Pages 185-195 Acute Hepatitic Onset of Liver GVHD Occurring 9 Months Post-transplant (Howard M. Shulman, Keith R. Loeb)....Pages 197-206 GVHD Manifesting as Sicca Syndrome (Cecilia C. S. Yeung, Howard M. Shulman)....Pages 207-214 Noninfectious Pulmonary Manifestation of GVHD: Bronchiolitis Obliterans Syndrome (Cecilia C. S. Yeung, Sahl Ali, Howard M. Shulman)....Pages 215-226 Kidney Involvement in GVHD (Abbie Ruth Bauer, Laura S. Finn, Sangeeta R. Hingorani)....Pages 227-236 Manifestations of Chronic GVHD in Other Organ Systems (Cecilia C. S. Yeung, Howard M. Shulman)....Pages 237-244 Back Matter ....Pages 245-251