The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology: Definitions, Criteria, Explanatory Notes, and Recommendations for Ancillary Testing

Description

This text presents comprehensive review of the recommendations of the Papanicolaou Society of Cytopathology for reporting results of respiratory cytology specimens along with advances in diagnostic, prognostic, and predictive immunohistochemical and molecular techniques which can be performed on cytology specimens.The majority of the text focuses on the standardized terminology and nomenclature for respiratory cytology as recommended by the Papanicolaou Society of Cytopathology. Each of the diagnostic categories are described in depth and formal definitions for each category are given along with cytologic criteria. Explanatory notes are given discussing limitations of the category as well as its malignancy risk and reproducibility. Management recommendations are supplied for each category. Sample reports documenting the preferred reporting format are also given. Each category is associated with a reference list establishing the evidence based nature of the categories. An in depth discussion of ancillary testing is provided, including the utilization of microbiologic culture, immunohistochemistry, and molecular techniques. Substantial emphasis is placed on molecular diagnostics necessary for optimization of personalized testing and the appropriate use of targeted therapies. The text represents a comprehensive resource for the state of the science of the cytologic diagnosis of respiratory lesions. Front Matter ....Pages i-ix Overview of Diagnostic Terminology and Reporting (Jalal B. Jalaly, Ioannis Ioannidis, Lester J. Layfield, Zubair Baloch)....Pages 1-6 Category I: Nondiagnostic (Lester J. Layfield, Zubair Baloch)....Pages 7-12 Category II: Negative (for Malignancy) (Lester J. Layfield, Zubair Baloch)....Pages 13-26 Category III: Atypical (Gordon H. Yu)....Pages 27-39 Category IV: Neoplastic (Benign) (Lester J. Layfield, Zubair Baloch)....Pages 41-49 Category IV: Neoplasm—Undetermined Malignant Potential (Tamar C. Brandler, Andre Luis Moreira)....Pages 51-80 Category V: Suspicious for Malignancy (Leslie G. Dodd, Allen Cole Burks)....Pages 81-94 Category VI: Malignant (Lester J. Layfield, Esther Diana Rossi, Andre Luis Moreira, Zubair Baloch)....Pages 95-124 Recommendations for Ancillary Testing (Sinchita Roy-Chowdhuri, Nikoletta Sidiropoulos)....Pages 125-142 Back Matter ....Pages 143-151