Antibiotic Drug Discovery: New Targets and Molecular Entities

Description

Recent years have seen a resurgence of antibiotic drug discovery. This book brings together the relevant information to assess the state-of-the-art. It identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities. Addressing the need for continued investment in antibiotic drug development, the book provides a point of reference for the rapidly expanding infectious disease research community. In addition to its attention on new targets, the book focusses on the medicinal chemistry and chemistry of the targets. Within this framework, chapters from leading researchers in academia and industry address findings in important areas such as biofilm production, narrow spectrum antibiotics and novel antibacterials from previously uncultured soil bacteria. This book will be a useful resource for postgraduate students and researchers in medicinal chemistry wishing to understand the latest approaches to antibiotic drug discovery. Content: Treatment of Clostridium difficile Infections Targeting Purine Biosynthesis for Antibacterial Drug Design Inhibitors of Biofilm Production Narrow Spectrum Antibacterial Agents The LPS Transport Pathway: A New Target for the Development of Gram-Negative Antibiotics The Discovery of Teixobactin Emerging Targets in Anti-Tubercular Drug Design Antibacterial Leads Targeting Isoprenoid Biosynthesis