ENGLISH

Allosterism in drug discovery

By Terry Kenakin , David Rotella , Jesús Giraldo , Sylvain Celanire , David Thurston , Dario Doller , Xinyan Huang , Stephan Schann , Tom Costa , Andrés A. Trabanco , Corey Hopkins , Andrew Alt , Ken Jacobsen , Phil Carpino , Anna-Liisa Brownell , Katie Lynne Strong , Craig Jamieson , Mark M. Levandoski , Benny Bang-Andersen , Stefan Knapp , Maurizio Botta , Shelli McAlpine

Book information

Publisher
Royal Society of Chemistry
Year
2016
ISBN
1782624597, 978-1-78262-459-2, 978-1-78262-927-6, 978-1-78262-969-6
DOI
10.1039/9781782629276
Language
english
Format
PDF
Filesize
20 MB (20654911 bytes)
Edition
Gld
Pages
458\455
Time added
2016-12-28 23:29:09

Description

Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery. Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and industrialists interested in understanding allosteric interactions. The book provides an in-depth review of research using small molecules as chemical probes and drug candidates that interact allosterically with proteins of relevance to life sciences and human disease. Knowledge of these interactions can then be applied in the discovery of the novel therapeutics of the future. This book will be useful for people working in all disciplines associated with drug discovery in academia or industry, as well as postgraduate students who may be working in the design of allosteric modulators.

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