ENGLISH

Phosphodiesterases as Drug Targets

By Marco Conti , Sharron H. Francis , Christian Schudt , Armin Hatzelmann , Rolf Beume (auth.) , Miles D. Houslay (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2011
ISBN
3642179681, 9783642179686
DOI
10.1007/978-3-642-17969-3
ISSN
0171-2004
Google Books ID
kppXheTIUYcC
Language
english
Format
PDF
Filesize
5 MB (5663651 bytes)
Series
Handbook of Experimental Pharmacology 204
Edition
1
Pages
522\538
Orientation
yes
Scanned
no
Time added
2012-02-14 18:00:00
Pharmacology/Toxicology; Medicinal Chemistry; Prot

Description

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

Similar books