ENGLISH

Mitochondrial Diseases: Models and Methods

By P. Lestienne (auth.) , Dr. Patrick Lestienne (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1999
ISBN
978-3-642-64166-4, 978-3-642-59884-5
DOI
10.1007/978-3-642-59884-5
Language
english
Format
PDF
Filesize
9 MB (9012384 bytes)
Edition
1
Pages
396\396
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
general; Human GeneticsMolecular Medicine; Cell Biology; Biochemistry

Description

This volume covers the molecular aspects of mitochondrial disorders and their diagnosis with particular emphasis on the mitochondrial tRNA structure and its various mutations. It further describes some key nuclear-encoded proteins involved in energy transduction and presents new aspects of mitochondrial DNA, e.g. its in vivo conformational changes, and models of deletions and partition. Moreover, it discusses the involvement of mitochondria in apoptosis, hormonal response and ageing. This volume also investigates the precise molecular import mechanisms of particular proteins and specific tRNAs into plants and yeast mitochondria relevant to human diseases.

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