Respiratory System

Description

This is the second edition of a monograph which provided a concise approach to an understanding of the spontaneous and induced lesions in the respiratory system of laboratory animals, especially the rat, mouse, and hamster. This expanded edition keeps the basic format of the first edition but provides much more information applicable to the study of toxicologic pathology. For example, the effects of inhaled toxicants of the upper respiratory tract are presented in detail in relation to the specific cells affected, based upon their precise morphology and function discerned at the ultrastructural level. This approach is followed through the entire volume, with precise identification of the cells preceding consideration of perturbations caused by toxicants of other etiologic agents. Current understanding of the nature and significance of pathologic lesions is probed throughout the volume. Although toxicologic pathology is emphasized, experimental pathologists and other scientists will find this book especially useful. Front Matter....Pages I-XV Front Matter....Pages 1-1 Normal Morphology of the Nasal Passages in Laboratory Rodents....Pages 3-17 Proliferative and Metaplastic Lesions in Nonolfactory Nasal Epithelia Induced by Inhaled Chemicals....Pages 18-28 Nonneoplastic Lesions of the Olfactory Mucosa....Pages 28-43 Microscopic Anatomy of Toxicologically Important Regions of the Larynx of the Rat, Mouse, and Hamster....Pages 43-51 Effects of Xenobiotics on the Larynx of the Rat, Mouse and Hamster....Pages 51-57 Development of Syrian Golden Hamster Tracheal Epithelium During Prenatal and Immediate Postnatal Stages....Pages 58-76 Morphological Response of Respiratory Epithelium to Carcinogens, Syrian Hamster ( Mesocricetus auratus W.)....Pages 77-87 Nasal Neoplasia....Pages 87-104 Hemangiosarcoma, Nasal Cavity, Mouse....Pages 105-107 Neuroendocrine Hyperplasias and Tumors, Larynx and Trachea, Syrian Hamster....Pages 107-116 Murine Respiratory Mycoplasmosis, Rat and Mouse....Pages 117-128 Rat Coronavirus Infection, Upper Respiratory Tract, Rat....Pages 128-131 Front Matter....Pages 133-133 Structure and Function of the Lung....Pages 135-150 In Vitro Differentiation of an Epithelial Stem Cell Line Derived from the Fetal Syrian Hamster Lung....Pages 150-158 Comparative Aspects of Pulmonary Carcinogenesis....Pages 158-173 Alveolar/Bronchiolar Hyperplasia, Adenoma and Carcinoma, Lung, Rat....Pages 174-183 Naturally Occurring Pulmonary Tumors in Rodents....Pages 183-206 Squamous Cell Carcinoma, Lung, Rat....Pages 207-212 Radiation-Induced Squamous Cell Carcinoma, Lung, Rat....Pages 213-218 Radiation-Induced Adenocarcinoma, Lung, Rat....Pages 218-223 Front Matter....Pages 133-133 Radiation-Induced Sarcomas, Lung, Rat....Pages 223-226 Radiation-Induced Adenosquamous Carcinoma, Lung, Rat....Pages 226-229 Pleural Mesothelioma, Syrian Hamster....Pages 229-233 Metastatic Tumors, Lung, Mouse....Pages 234-251 Bleomycin-Induced Injury, Mouse. A Model for Lung Injury....Pages 252-259 Fibroblast Interactions with Epithelial Cells in Lung Injury and Repair....Pages 259-265 Fibroblast Interactions with Alveolar and Interstitial Macrophages. Models: Silicosis and Asbestosis in the Mouse....Pages 265-269 Pulmonary Lipidosis, Rat....Pages 270-272 Alveolar Lipoproteinosis, Rat....Pages 272-278 Fly Ash Pneumoconiosis, Hamster....Pages 278-281 Asbestosis, Hamster....Pages 282-285 Squamous Metaplasia, Lung, Rat....Pages 285-292 Pulmonary Hair Embolism, Rat....Pages 293-302 Goblet Cell Metaplasia, Lung, Rat....Pages 303-307 Sendai Virus Infection, Lung, Mouse, and Rat....Pages 308-316 Pneumonia Virus of Mice Infection, Lung, Mouse, and Rat....Pages 317-321 Rat Coronavirus Infection, Lung, Rat....Pages 321-324 Cilia-Associated Respiratory Bacillus Infection, Rat, Mouse, and Rabbit....Pages 325-331 Pneumocystosis, Lung, Rat....Pages 331-337 Toxoplasmosis, Lung, Mouse, and Hamster....Pages 337-341 Front Matter....Pages 133-133 Aspergillosis and Mucormycosis, Lung, Rat....Pages 341-344 Back Matter....Pages 345-357